Alphabetical Listing of Primary Antibodies:
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5-9
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A
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B
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C
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D
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E
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F
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G
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J
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K
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M
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Y
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Alphabetical Listing of Proteins:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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T
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Peptides
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Secondary Antibodies
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ELISA Kits
Phospho-p44/42 MAPK (ERK1/2 Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-007-283037
Buy MAPK1 antibody -
Volume:
0.1 ml ($240.00)
Related Product Names:
- MAPK1 antibody; MAPK1; ERK; MAP kinase; p42; Phospho-p44/42 MAPK (ERK1/2
- Anti-Phospho-p44/42 MAPK (ERK1/2; EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1; Mitogen-activated protein kinase 1
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
MAPK1
Gene Name Synonym:
ERK; MAP kinase; p42
Gi #:
N/A
NCBI Acc #:
NP_002736.3
Swiss Prot Acc #:
P28482
Length (aa):
N/A
Mol. Weight (Da):
41390
Chrom Location:
N/A
Immunogen:
Synthetic phospholyrated peptide (KLH coupled) corresponding to residues around Thr202/Tyr204 of human p44 MAP kinase (Erk1)
Concentration:
1 mg/ml
Positive Control:
NIH3T3 cell lysates stimulated with PDGF
Composition:
PBS containing 50% glycerol
Notes:
Western Blotting (1:5000)
Isotype:
IgG
Positive Control:
NIH3T3 cell treated with PDGF-BB
Source/Host:
Rabbit
Clonality:
Polyclonal
Crossreactivity:
Human, Mouse, Rat
Format:
100 ug IgG in 100ul volume of PBS containing 50% glycerol
Storage:
stable for 1 years at -20C from date of shipment
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for MAPK1 ANTIBODY:
WB: Tested
TESTING: (
secondary reagents
and
protocols
)
Test :
( anti-MAPK1 )
MAPK1 antibody Test image
MAPK1 ANTIBODY TARGET DESCRIPTION:
Synonym Names for MAPK1 antibody:
MAPK1; ERK; MAP kinase; p42; Anti-Phospho-p44/42 MAPK (ERK1/2; EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1; Mitogen-activated protein kinase 1
ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways.
When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase(ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.
Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Cofactor:
Magnesium (By similarity).
Enzyme Regulation:
Activated by phosphorylation on tyrosine and threonine in response to insulin and NGF. Both phosphorylations are required for activity (By similarity).
Subunit:
Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with its substrates HSF4 and ARHGEF2. Interacts with NISCH.
Domain:
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Ptm:
Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.
Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Similarity:
Contains 1 protein kinase domain.
Phospho-p44/42 MAPK (ERK1/2 reacts with human, mouse, rat.
OMIM:
176948; gene. [
NCBI
/
EBI
]
Products similar to MAPK1 antibody:
IgG
Phospho-p38 MAPK (Thr180/Tyr182), IgG
MAPK, IgG
ERK1 & ERK2, IgG
Ephrin-B1, IgG
ERK1, IgG
Peptide
P38 MAPK(Phospho-Tyr182) Antibody Blocking Peptide, Peptide
p44/42 MAP Kinase Phospho-Thr202) Antibody Blocking Peptide, Peptide
P38 MAPK(Phospho-Thr180) Antibody Blocking Peptide, Peptide
SEK1/MKK4 (Phospho-Ser80) Antibody Blocking Peptide, Peptide
p44/42 MAP Kinase (Phospho-Tyr204) Antibody Blocking Peptide, Peptide
Protein
Eukaryotic translation initiation factor 3 subunit 4, Protein
Mitogen-activated protein kinase 12, Protein
Mitogen-activated protein kinase 3, Protein
Mitogen-activated protein kinase 1, Protein
ERK1/MAPK3 Human, Protein
PRODUCT INTERACTIONS:
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk-1 Human, Protein
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
ELK-1, IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
ELK1 phospho S383, IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk1 (Phospho-Ser389), IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk1 (Phospho-Thr417), IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk1 (Ab-389), IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk1 (Ab-417), IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk-1 (Phospho-Ser383), IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk-1 (Ab-383), IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk-1 (Phospho-Ser383) Antibody Blocking Peptide, Peptide
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk1 (Phospho-Ser389) Antibody Blocking Peptide, Peptide
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
Elk1 (Phospho-Thr417) Antibody Blocking Peptide, Peptide
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
ELK1 (ELK1. member of ETS oncogene family), IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
ELK1, IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
ELK1, IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
MBP, Native_Protein
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
MBP, IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
MBP, IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
MBP, IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
MBP, IgG
(GenWay Catalog #: 18-007-283037)
.
Phospho-p44/42 MAPK (ERK1/2
interacts
with
MBP, IgG
(GenWay Catalog #: 18-007-283037)
.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for MAPK1 ANTIBODY:
Background references for antibody target are not specific to GenWay products
1) Smalley, K. (2003) Int. J. Cancer, 104, 527-532
2) Johnson G L and Lapadat R (Johnson, G.L. Lapadat, R. 2002) Science, 298, 1911-1912
3) Kolch, W. (2000) Biochem. J. 351, 289-305
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
MAPK1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of MAPK1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about MAPK1 antibody, all related information, articles, resources about MAPK1 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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