SERPINE1 antibody, PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) Antibody, Sheep Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) Antibody, Sheep Polyclonal Antibody

Catalog Number: 18-731-285133

Buy SERPINE1 antibody -

Volume:

Related Product Names:

- SERPINE1 antibody; SERPINE1; PAI1; PLANH1; PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1)
- PAI-1; PAI; Endothelial plasminogen activator inhibitor; Plasminogen activator inhibitor 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: SERPINE1	Gene Name Synonym: PAI1; PLANH1
Gi #: N/A	NCBI Acc #: NP_000593.1	Swiss Prot Acc #: P05121
Length (aa): N/A	Mol. Weight (Da): 45060	Chrom Location: N/A

Immunogen: Recombinant Human PAI-1

PH: 7.2

Buffer: 20mM Phosphate. 150mM Sodium Chloride

Preservative: 0.09% Sodium Azide

Source/Host: Sheep

Clonality: Polyclonal

Format: Ig Fraction

Storage: <= -20C

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

SERPINE1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for SERPINE1 antibody: SERPINE1; PAI1; PLANH1; PAI-1; PAI; Endothelial plasminogen activator inhibitor; Plasminogen activator inhibitor 1

Function: This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.

Subunit: Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.

Subcellular Location: Secreted.

Tissue Specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.

Ptm: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.

Disease: Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) [MIM:173360]. This deficiency is characterized by abnormal bleeding due to SERPINE1 defect in the plasma.

Disease: High concentrations of SERPINE1 have been associated with thrombophilia [MIM:188050]; an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.

Similarity: Belongs to the serpin family.

OMIM: 173360; gene. [NCBI / EBI]
188050; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Complement and coagulation cascades 04610
Reactome Event:Hemostasis 109582

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PRODUCT INTERACTIONS:

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Human Orosomucoid, ELISA_Kits (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Rat Alpha 1-Acid Glycoprotein, ELISA_Kits (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with ALPHA 1 ACID GLYCOPROTEIN, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with alpha 1 Acid Glycoprotein, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Sheep A' Alpha1 acid glycoprot., IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Goat A' Alpha 1 Acid Glycoprot., IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Alpha 1-Acid Glycoprotein, Native_Protein (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with alpha 1 Acid Glycoprotein antibody, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with alpha 1 Acid Glycoprotein, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with alpha 1 Acid Glycoprotein (HRP)*B1G1, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with alpha 1 Acid Glycoprotein, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with VITRONECTIN, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Vitronectin [VN58-1], IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Vitronectin [BV1], IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Vitronectin EIA Kit, ELISA_Kits (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Vitronectin, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Vitronectin, Inhibitory, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Rabbit anti Vitronectin, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Rabbit anti Mouse Vitronectin, IgG (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Human Vitronectin, Native_Protein (GenWay Catalog #: 18-731-285133).

PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) interacts with Vitronectin [VIT-2], IgG (GenWay Catalog #: 18-731-285133).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

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Precautions: SERPINE1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of SERPINE1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SERPINE1 antibody, all related information, articles, resources about SERPINE1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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