HP protein, Haptoglobin beta chain: Human, Recombinant, E Coli recombinant protein

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Peptides \| Secondary Antibodies \| ELISA Kits

Haptoglobin beta chain: Human, Recombinant, E Coli recombinant protein

Catalog Number: 10-731-288168

Buy HP protein -

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Related Product Names:

- HP protein; HP; Haptoglobin beta chain: Human, Recombinant, E Coli
- Hp, Bp; N/A; Haptoglobin

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: HP	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_001119574.1	Swiss Prot Acc #: P00738
Length (aa): N/A	Mol. Weight (Da): 45205	Chrom Location: N/A

Source/Host: E Coli

Purity/Purification: >95% by SDS-PAGE

Format: Liquid

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for HP PROTEIN:

SDS-Page: Tested

TESTING: (secondary reagents and protocols )

Test : ( anti-HP protein )

HP protein Test image

HP PROTEIN TARGET DESCRIPTION:

Synonym Names for HP protein: HP; Hp, Bp; N/A; Haptoglobin

Haptoglobin is a glycoprotein secreted in the blood plasma that binds free haemoglobin thereby inhibiting its oxidative activity and preventing iron loss following haemolysis. Haptoglobin also regulates the activity of many cell types of the immune system and is an extracellular chaperone. Haptoglobin is produced mostly by hepatocytes but also by other tissues: e.g. skin, lung and kidney. Haptoglobin is a tetramer of two ?- and two ?-chains, connected by disulfide bridges. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis.
RANDOX recombinant Haptoglobin ?-chain comprises a 245 amino acid fragment (162-406) corresponding to the mature haptoglobin ?-chain and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Function: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.

Subunit: Tetramer of two alpha and two beta chains.

Subcellular Location: Secreted.

Tissue Specificity: Expressed by the liver and secreted in plasma.

Polymorphism: In the human populations there are two major allelic forms, alpha-1 with 83 residues and alpha-2 with 142 residues. These alleles determine the 3 major phenotypes HP*1F/HP*1S and HP*2FS. The two main alleles of HP*1 are called HP*1F (fast) and HP*1S (slow).

Similarity: Belongs to the peptidase S1 family [view classification].

Similarity: Contains 1 peptidase S1 domain [view classification].

Similarity: Contains 2 Sushi (CCP/SCR) domains.

OMIM: 140100; gene. [NCBI / EBI]

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SUGGESTED PROTEIN REAGENTS - GenWay offers reagents to facilitate your research with cell-based assays, Mass Spectrometry, standards, calibrators, Western blot, cell culture, antibiotics, microwell substrates, and more!

BACKGROUND REFERENCES for HP PROTEIN:

Background references for antibody target are not specific to GenWay products

1: Yang, F. et al., Proc. Natl. Acad. Sci. USA 80 (19):5875-5879 (1983).
Kurosky, A. et al., Proc. Natl. Acad. Sci. USA 77 (6): 3388-3392 (1980).

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: HP protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of HP protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about HP protein, all related information, articles, resources about HP protein are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

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