BMI1 antibody, Anti-BMI-1 (B lymphoma Mo-MLV insertion region) Antibody, Goat N/A Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

Anti-BMI-1 (B lymphoma Mo-MLV insertion region) Antibody, Goat N/A Antibody

Catalog Number: 18-732-292198

Buy BMI1 antibody -

Size:

Related Product Names:

- BMI1 antibody; BMI1; PCGF4; RNF51; Anti-BMI-1 (B lymphoma Mo-MLV insertion region)
- IgG Fraction of Anti-Human BMI-1 (B lymphoma Mo-MLV insertion region) [Goat]; Polycomb group RING finger protein 4; RING finger protein 51; Polycomb complex protein BMI-1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: BMI1	Gene Name Synonym: PCGF4; RNF51
Gi #: N/A	NCBI Acc #: NP_005171.4	Swiss Prot Acc #: P35226
Length (aa): N/A	Mol. Weight (Da): 36949	Chrom Location: N/A

Antigen: Human BMI-1

Peptide Sequence: C-D-S-G-S-D-K-A-N-S-P-A-G-G

Immunogen: This purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 252-264 of Human BMI-1 (B lymphoma Mo-MLV insertion region). The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi-1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Swiss Prot accession number P35226. Locus Link ID 648. Shows 100% identity with mouse sequence.

Family: Transcription Factor

Fraction: IgG

Application Note: This purified antibody has been tested for use in ELISA against the immunizing peptide. Reactivity in other immunoassays is unknown.

Recommended Dilution: This product has been assayed by ELISA against 0.1 ug of the immunizing peptide. A 1:10,000 dilution of the antibody was noted against the peptide.

Purity and Specificity: This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above.

Antibody Concentration: 5.0 mg/ml (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Source/Host: Goat

Purity/Purification: IgG Fraction

Crossreactivity: Human

Format: Liquid (sterile filtered)

Storage: -20C or Colder

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for BMI1 ANTIBODY:

ELISA, WB, IP: Tested

TESTING: (secondary reagents and protocols )

Not Available

BMI1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for BMI1 antibody: BMI1; PCGF4; RNF51; IgG Fraction of Anti-Human BMI-1 (B lymphoma Mo-MLV insertion region) [Goat]; Polycomb group RING finger protein 4; RING finger protein 51; Polycomb complex protein BMI-1

Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Subunit: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive complex 1-like at least composed of PHC2, BMI1, RING1 and RNF2. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1.

Subcellular Location: Nucleus. Cytoplasm.

Ptm: May be polyubiquitinated; which does not lead to proteasomal degradation.

Disease: Cooperates with the MYC oncogene to produce B-lymphomas.

Similarity: Contains 1 RING-type zinc finger.

Anti-BMI-1 (B lymphoma Mo-MLV insertion region) reacts with human.

OMIM: 164831; gene. [NCBI / EBI]

Products similar to BMI1 antibody:

IgG

Rabbit anti BMI-1, IgG

BMI1 polycomb ring finger oncogene (BMI1), IgG

BMI-1, IgG

PCGF4, IgG

BMI-1, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: BMI1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of BMI1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about BMI1 antibody, all related information, articles, resources about BMI1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved