Alphabetical Listing of Primary Antibodies:
f
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
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0-4
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5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
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ELISA Kits
Anti-VDAC/Porin Antibody, Rabbit N/A Antibody
Catalog Number: 18-732-292487
Buy Anti-VDAC/Porin antibody -
Size:
0.2 mg ($330.00)
Related Product Names:
- Anti-VDAC/Porin antibody; Anti-VDAC/Porin
- Affinity Purified Anti-VDAC/Porin [Rabbit]
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
N/A
Gene Name Synonym:
N/A
Gi #:
N/A
NCBI Acc #:
N/A
Swiss Prot Acc #:
P21796
Length (aa):
N/A
Mol. Weight (Da):
N/A
Chrom Location:
N/A
Antigen:
VDAC / Porin
Immunogen:
This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 185-197 of Human VDAC1/Porin1.
Protein Sequence:
Human VDAC1/Porin1, 283 aa, predicted MW 30.8 kDa
1 mavpptyadl gksardvftk gygfglikld lktksengle ftssgsante ttkvtgslet
61 kyrwteyglt ftekwntdnt lgteitvedq larglkltfd ssfspntgkk nakiktgykr
121 ehinlgcdmd fdiagpsirg alvlgyegwl agyqmnfeta ksrvtqsnfa vgyktdefql
181 htnvndgtef ggsiyqkvnk kletavnlaw tagnsntrfg iaakyqidpd acfsakvnns
241 sliglgytqt lkpgikltls alldgknvna gghklglgle fqa
Family:
Loading Control
Fraction:
Affinity Purified IgG
Application Note:
This affinity purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band at ~30-33 kDa in size corresponding to VDAC/Porin by western blotting in the appropriate cell lysate or extract.
Recommended Dilution:
ELISA 1:10,000 - 1:40,000
WESTERN BLOT 1:500 - 1:2,000
IF MICROSCOPY User Optimized
OTHER APPLICATIONS User Optimized
Physical State:
Liquid (sterile filtered)
Purity and Specificity:
This affinity purified antibody is directed against human VDAC1/Porin1 protein. The productwas affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggestthat this antibody would react with VDAC1/Porin1 from a wide range or organisms, including avian, mammalian, aquaticand reptilian sources based on 100% homology for the immunogen sequence. Cross reactivity will occur with all formsof VDACs including VDAC1, VDAC2 (4 isoforms) and VDAC3 (2 isoforms). Such broad reactivity makes this antibodyuseful as an excellent loading control (mitochondrial).
Antibody Concentration:
0.4 mg/ml (by UV absorbance at 280 nm)
Stabilizer:
None
Ship Code:
Dry Ice
Source/Host:
Rabbit
Purity/Purification:
Affinity Purified
Crossreactivity:
Loading Control
Format:
Liquid (sterile filtered)
Storage:
-20C or Colder
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for ANTI-VDAC/PORIN ANTIBODY:
ELISA, WB, IP: Tested
TESTING: (
secondary reagents
and
protocols
)
Application ( anti-Anti-VDAC/Porin )
Anti-VDAC/Porin antibody licat image
ANTI-VDAC/PORIN ANTIBODY TARGET DESCRIPTION:
Synonym Names for Anti-VDAC/Porin antibody:
N/A; Affinity Purified Anti-VDAC/Porin [Rabbit]
VDAC (also known as Voltage-dependent anionselectivechannel protein 1, Outer mitochondrial membraneprotein porin 1, Plasmalemmal porin, Porin 31HL) is an outermembrane mitochondrial protein. The VDAC proteins are ~30-33 kDa (some isoforms are larger - see below). The VDACproteins are thought to form aqueous channels, or pores,through which adenine nucleotides cross the outer mitochondrialmembrane. VDACs have been implicated in theformation of the mitochondrial permeability transition porecomplex in apoptotic cells. This complex, formed by VDAC,adenine nucleotide translocator (ANT), and cyclophilin D(CypD), is thought to allow the mitochondria to undergometabolic uncoupling and irreversible morphologic changes thatultimately destroy the mitochondria during apoptosis. VDACsare highly expressed in heart, liver and skeletal muscle, whereconcentrations of mitochondria are at their highest. Thisantibody can be used as a loading control with whole celllysates and total mitochondrial preparations.
Anti-VDAC/Porin reacts with loading control.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for ANTI-VDAC/PORIN ANTIBODY:
Background references for antibody target are not specific to GenWay products
Liu T et al. Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene23:39-48 (2004).
Suarez J et al. In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy. Am J Physiol HeartCirc Physiol 286:H68-75 (2004).
Leary SC et al. Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase. Hum Mol Genet13:1839-48 (2004).
Jonas EA et al. Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proc NatlAcad Sci U S A 101:13590-5 (2004).
Liu J et al. Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis. Cancer Res 63:1153-6 (2003).
Gustafsson AB et al. TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain iscardioprotective. Circulation 106:735-9 (2002).
Le Mellay V et al. Negative regulation of mitochondrial VDAC channels by C-Raf kinase. BMC Cell Biol 3:14 (2002).
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
Anti-VDAC/Porin antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of Anti-VDAC/Porin antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Anti-VDAC/Porin antibody, all related information, articles, resources about Anti-VDAC/Porin antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.
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