ALPL secondary antibody, Alkaline Phosphatase Conjugated Affinity Purified Anti-SHEEP IgG F(c) (RABBIT) Secondary Antibody

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Alkaline Phosphatase Conjugated Affinity Purified Anti-SHEEP IgG F(c) (RABBIT) Secondary Antibody

Catalog Number: 25-732-294476

Buy ALPL secondary antibody -

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Related Product Names:

- ALPL secondary antibody; ALPL; Alkaline Phosphatase Conjugated Affinity Purified Anti-SHEEP IgG F(c) (RABBIT)
- Alkaline Phosphatase Conjugated Affinity Purified anti-Sheep IgG F(c) [Rabbit]; EC 3.1.3.1; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Alkaline phosphatase, tissue-nonspecific isozyme

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: ALPL	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_000469.3	Swiss Prot Acc #: P05186
Length (aa): N/A	Mol. Weight (Da): 57305	Chrom Location: N/A

Antigen: F(c)

Immunogen: Sheep IgG F(c) fragment

Family: Affinity Purified

Fraction: Affinity Purified IgG

Purity Note: This product was prepared from monospecific antiserum by immunoaffinity chromatography using Sheep IgG coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti- Alkaline Phosphatase (calf intestine), anti-Rabbit Serum, Sheep IgG, Sheep IgG F(c) and Sheep Serum. No reaction was observed against Sheep IgG F(ab’)2.

Conjugation: Alklaine Phosphatase

Conjugation Reference: Modified from Avarameas and Ternyrock, Immunochemistry 32; 1175 1971.

Application: suitable for immunoblotting (western or dot blot), ELISA and immunohistochemistry as well as other phosphatase-antibody based enzymatic assays requiring lot-to-lot consistency.

Recommended Dilution: This product has been assayed against 1.0 ug of Sheep IgG in a standard capture ELISA using pNPP p-nitrophenyl phosphate code # NPP-10 as a substrate for 30 minutes at room temperature. A working dilution of 1:1,300 to 1:5,400 of the reconstitution concentration is suggested for this product. Optimal titers for other applications should be determined by the researcher.

Physical State: Liquid (sterile filtered)

Antibody Concentration: 0.65 mg/ml (by UV absorbance at 280 nm)

Label: Alkaline Phosphatase (Calf Intestine) (Molecular Weight 140,000 daltons)

Buffer: 0.05 M Tris Chloride, 0.15M Sodium Chloride, 0.001M Magnesium Chloride, 0.0001M Zinc Chloride, 50% (v/v) Glycerol; pH 8.0

Stabilizer: 10 mg/ml Bovine Serum Albumin (BSA) IgG and Protease free

Ship Code: WETICE

Source/Host: Rabbit

Purity/Purification: Affinity Purified

Crossreactivity: Sheep IgG F(c)

Format: Liquid (sterile filtered)

Storage: 4C

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for ALPL SECONDARY ANTIBODY:

WB, ELISA, IHC: Tested

TESTING: (secondary reagents and protocols )

Not Available

ALPL SECONDARY ANTIBODY TARGET DESCRIPTION:

Synonym Names for ALPL secondary antibody: ALPL; Alkaline Phosphatase Conjugated Affinity Purified anti-Sheep IgG F(c) [Rabbit]; EC 3.1.3.1; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Alkaline phosphatase, tissue-nonspecific isozyme

Function: This isozyme may play a role in skeletal mineralization.

Catalytic Activity: A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor: Binds 1 magnesium ion (By similarity).

Cofactor: Binds 2 zinc ions (By similarity).

Subunit: Homodimer.

Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor.

Ptm: Glycosylated.

Disease: Defects in ALPL are a cause of hypophosphatasia infantile (hypophosphatasia) [MIM:241500]; an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto).

Disease: Defects in ALPL are a cause of hypophosphatasia childhood (hypophosphatasia) [MIM:241510].

Disease: Defects in ALPL are a cause of hypophosphatasia adult type (hypophosphatasia) [MIM:146300].

Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

Similarity: Belongs to the alkaline phosphatase family.

Alkaline Phosphatase Conjugated Affinity Purified Anti-SHEEP IgG F(c) (RABBIT) reacts with sheep igg f(c).

OMIM: 146300; phenotype. [NCBI / EBI]
171760; gene. [NCBI / EBI]
241500; phenotype. [NCBI / EBI]
241510; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Folate biosynthesis 00790
KEGG pathway: gamma-Hexachlorocyclohexane degradation 00361

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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: ALPL secondary antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ALPL secondary antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ALPL secondary antibody, all related information, articles, resources about ALPL secondary antibody are being stored on our online database. Let us know if you have questions regarding this product.

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