NEMO antibody, NFkappaB essential modulator Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

NFkappaB essential modulator Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-001-30027

Buy NEMO antibody -

Size:

Related Product Names:

- NEMO antibody; NEMO; IP; IP1; IP2; FIP3; NEMO; FIP-3; Fip3p; IKK-gamma; NFkappaB essential modulator
- Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: NEMO	Gene Name Synonym: IP; IP1; IP2; FIP3; NEMO; FIP-3; Fip3p; IKK-gamma
Gi #: 4504631	NCBI Acc #: NP_003630.1	Swiss Prot Acc #: Q7LBY6
Length (aa): 419	Mol. Weight (Da): 48198	Chrom Location: Xq28

Linear Protein Map with Immunogenic Epitope Marked (sequence source from above GI#)

Immunogen: Reacts with residues 385-399 [RRSPPEEPPDFCCPK] of the IKK-g protein.

Source/Host: Rabbit

Purity/Purification: Affinity Purified

Clonality: Polyclonal

Crossreactivity: Human

Format: PBS containing 0.02% sodium azide.

Storage: 2 degree C to 8 degree C for 3 months and at -20 degree C for long term. Avoid frequent freeze and thaw.

Stability: 12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for NEMO ANTIBODY:

ELISA, WB: Tested

ICC, IHC: Not Tested

TESTING: (secondary reagents and protocols )

Western Blot: Western Blot analysis of IKK-g in Interleukin-1 stimulated 293 cells with anti-IKK-g at a 1:500 dilution. ( anti-NEMO )

NEMO antibody Western Blot image
NEMO

NEMO ANTIBODY TARGET DESCRIPTION:

Synonym Names for NEMO antibody: NEMO; IP; IP1; IP2; FIP3; NEMO; FIP-3; Fip3p; IKK-gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Summary: Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males (The International Incontinentia Pigmenti Consortium, 2000 [PubMed 10839543]). In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito (MIM 300337).[supplied by OMIM].

NFkappaB essential modulator reacts with human.

OMIM: NCBI [300248]

Pathways:
KEGG pathway: Apoptosis 04210
KEGG pathway: B cell receptor signaling pathway 04662
KEGG pathway: Epithelial cell signaling in Helicobacter pylori infection 05120
KEGG pathway: MAPK signaling pathway 04010
KEGG pathway: Pancreatic cancer 05212
KEGG pathway: T cell receptor signaling pathway 04660
KEGG pathway: Toll-like receptor signaling pathway 04620
Reactome Event:Immune System signaling 168256

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for NEMO ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Hai,T., Yeung,M.L., Wood,T.G., Wei,Y., Yamaoka,S., Gatalica,Z., Jeang,K.T. and Brasier,A.R.
     An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation
[2] Vinolo,E., Sebban,H., Chaffotte,A., Israel,A., Courtois,G., Veron,M. and Agou,F.
     A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation
[3] Wu,Z.H., Shi,Y., Tibbetts,R.S. and Miyamoto,S., et al.
     Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
[4] Fielding,A.B., Schonteich,E., Matheson,J., Wilson,G., Yu,X., Hickson,G.R., Srivastava,S., Baldwin,S.A., Prekeris,R. and, et al.
     Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis
[5] Reiley,W., Zhang,M., Wu,X., Granger,E. and Sun,S.C., et al.
     Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation
[6] , Galgoczy P., Rosenthal A., Platzer M.
     Human-mouse comparative sequence analysis of the NEMO gene reveals an alternative promoter within the neighboring G6PD gene.
[7] , Aradhya S., Bardaro T., Galgoczy P., Yamagata T., Esposito T., Patlan H., Ciccodicola A., Kenwrick S., Platzer M., D'Urso M., et al.
     Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes.
[8] , Galgoczy P., Platzer M.
     Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: NEMO antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of NEMO antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about NEMO antibody, all related information, articles, resources about NEMO antibody are being stored on our online database. Let us know if you have questions regarding this product.

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