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| P2Y purinoceptor 2 Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-001-30113 |
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| Related Product Names:
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P2RY2 antibody; P2RY2; P2RU1; P2Y purinoceptor 2
- P2Y2; P2U purinoceptor 1; P2U1; ATP receptor; Purinergic receptor; Purinergic receptor P2Y2 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: P2RY2 |
Gene Name Synonym: P2RU1 |
Gi #:
28872743 |
NCBI Acc #:
NP_788085.1 |
Swiss Prot Acc #:
P41231 |
Length (aa): 377 |
Mol. Weight (Da): 42290 |
Chrom Location: N/A |
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| Linear Protein Map with Immunogenic Epitope Marked (sequence source from above GI#)
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 Specificity: Synthetic peptide comprising residues 351-366 [DVLGSSEDSRRTESTP] of the human P2Y2 protein. Reacts with rat and mouse P2Y2.
Source/Host: Rabbit
Purity/Purification: Affinity Purified
Clonality: Polyclonal
Crossreactivity: Mouse, rat
Format: 0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.
Storage: 2 degree C to 8 degree C for 3 months and at -20 degree C for long term. Avoid frequent freeze and thaw.
Stability: 12 months at -20 degree C.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for P2RY2 ANTIBODY: |
| IHC, WB: Tested |
| ELISA, ICC: Not Tested |
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| TESTING: (secondary reagents and protocols
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IHC: P2Y2 staining (red color) in rat dorsal root ganglion. Tissue was fixed in 4% paraformaldehyde and cut into 10 micron sections. P2Y2 antibody was used at a dilution of 1:200 and secondary antibody at a dilution of 1:5000. ( anti-P2RY2 )P2RY2 antibody IHC image
 Western Blot: ( anti-P2RY2 )P2RY2 antibody Western Blot image
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| P2RY2 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for P2RY2 antibody: P2RY2; P2RU1; P2Y2; P2U purinoceptor 1; P2U1; ATP receptor; Purinergic receptor; Purinergic receptor P2Y2
Function: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Subcellular Location: Membrane; multi-pass membrane protein.
Tissue Specificity: Spleen, testis, kidney, liver, lung, heart and brain.
Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].
Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.
P2Y purinoceptor 2 reacts with mouse, rat.
OMIM: 600041; gene. [NCBI / EBI]
Pathways:
KEGG pathway: Neuroactive ligand-receptor interaction 04080
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for P2RY2 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Chen,Y., Corriden,R., Inoue,Y., Yip,L., Hashiguchi,N., Zinkernagel,A., Nizet,V., Insel,P.A. and Junger,W.G.
ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors
[2] Pines,A., Bivi,N., Vascotto,C., Romanello,M., D'Ambrosio,C., Scaloni,A., Damante,G., Morisi,R., Filetti,S., Ferretti,E.,, et al.
Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway
[3] Henriksen,Z., Hiken,J.F., Steinberg,T.H. and Jorgensen,N.R., et al.
The predominant mechanism of intercellular calcium wave propagation changes during long-term culture of human osteoblast-like cells
[4] Wihlborg,A.K., Balogh,J., Wang,L., Borna,C., Dou,Y., Joshi,B.V., Lazarowski,E., Jacobson,K.A., Arner,A. and Erlinge,D.
Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction
[5] Buscher,R., Hoerning,A., Patel,H.H., Zhang,S., Arthur,D.B., Grasemann,H., Ratjen,F. and Insel,P.A.
P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx
[6] Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T., et al.
Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.
[7] Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T., et al.
Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.
[8] Puhl H.L. III, Ikeda S.R., Aronstam R.S.
cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org). |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: P2RY2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of P2RY2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about P2RY2 antibody, all related information, articles, resources about P2RY2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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