NOG antibody, Noggin Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Noggin Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-001-30117

Buy NOG antibody -

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Related Product Names:

- NOG antibody; NOG; Noggin
- Noggin

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: NOG	Gene Name Synonym: N/A
Gi #: 21707595	NCBI Acc #: AAH34027.1	Swiss Prot Acc #: Q13253
Length (aa): 232	Mol. Weight (Da): 25774	Chrom Location: N/A

Linear Protein Map with Immunogenic Epitope Marked (sequence source from above GI#)

Antibody Specificity: Synthetic peptide comprising residues 156-170 [PVLYAWNDLGSRFWP] of the human Noggin protein.

Source/Host: Rabbit

Purity/Purification: Immunoaffinity Purified

Clonality: Polyclonal

Crossreactivity: Mouse, rat

Format: 0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.

Storage: 2 degree C to 8 degree C for 3 months and at -20 degree C for long term. Avoid frequent freeze and thaw.

Stability: 12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for NOG ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot: ( anti-NOG )

NOG antibody Western Blot image
NOG

NOG ANTIBODY TARGET DESCRIPTION:

Synonym Names for NOG antibody: NOG; Noggin

Function: Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity).

Subunit: Homodimer; disulfide-linked (By similarity).

Subcellular Location: Secreted protein.

Disease: Defects in NOG are the cause of symphalangism proximal syndrome (SYM1) [MIM:185800]. SYM1 is characterized by the hereditary absence of the proximal interphalangeal (PIP) joints (Cushing symphalangism). Severity of PIP joint involvement diminishes towards the radial side. Distal intrphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conducive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone.

Disease: Defects in NOG are the cause of multiple synostoses syndrome 1 (SYNS1) [MIM:186500]; also known as synostoses, multiple, with brachydactyly/symphalangism-brachydactyly syndrome. SYNS1 is characterized by tubular-shaped (hemicylindrical) nose with lack of alar flare, otosclerotic deafness, and multiple progressive joint fusions commencing in the hand. The joint fusions are progressive, commencing in the fifth proximal interphalangeal joint in early childhood (or at birth in some individuals) and progressing in an ulnar-to-radial and proximal-to-distal direction. With increasing age, ankylosis of other joints, including the cervical vertebrae, hips, and humeroradial joints, develop.

Disease: Defects in NOG are the cause of tarsal-carpal coalition syndrome (TCC) [MIM:186570]. TCC is an autosomal dominant disorder characterized by fusion of the carpals, tarsals and phalanges, short first metacarpals causing brachydactyly, and humeroradial fusion. TCC is allelic to SYM1, and different mutations in NOG can result in either TCC or SYM1 in different families.

Disease: Defects in NOG are a cause of stapes ankylosis with broad thumb and toes [MIM:184460]. Stapes ankylosis with broad thumb and toes is a congenital autosomal dominant disorder that includes hyperopia, a hemicylindrical nose, broad thumbs, great toes, and other minor skeletal anomalies but lacked carpal and tarsal fusion and symphalangism.

Similarity: Belongs to the noggin family.

Function: Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity).

Subunit: Homodimer; disulfide-linked (By similarity).

Subcellular Location: Secreted protein.

Disease: Defects in NOG are the cause of symphalangism proximal syndrome (SYM1) [MIM:185800]. SYM1 is characterized by the hereditary absence of the proximal interphalangeal (PIP) joints (Cushing symphalangism). Severity of PIP joint involvement diminishes towards the radial side. Distal intrphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conducive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone.

Disease: Defects in NOG are the cause of multiple synostoses syndrome 1 (SYNS1) [MIM:186500]; also known as synostoses, multiple, with brachydactyly/symphalangism-brachydactyly syndrome. SYNS1 is characterized by tubular-shaped (hemicylindrical) nose with lack of alar flare, otosclerotic deafness, and multiple progressive joint fusions commencing in the hand. The joint fusions are progressive, commencing in the fifth proximal interphalangeal joint in early childhood (or at birth in some individuals) and progressing in an ulnar-to-radial and proximal-to-distal direction. With increasing age, ankylosis of other joints, including the cervical vertebrae, hips, and humeroradial joints, develop.

Disease: Defects in NOG are the cause of tarsal-carpal coalition syndrome (TCC) [MIM:186570]. TCC is an autosomal dominant disorder characterized by fusion of the carpals, tarsals and phalanges, short first metacarpals causing brachydactyly, and humeroradial fusion. TCC is allelic to SYM1, and different mutations in NOG can result in either TCC or SYM1 in different families.

Disease: Defects in NOG are a cause of stapes ankylosis with broad thumb and toes [MIM:184460]. Stapes ankylosis with broad thumb and toes is a congenital autosomal dominant disorder that includes hyperopia, a hemicylindrical nose, broad thumbs, great toes, and other minor skeletal anomalies but lacked carpal and tarsal fusion and symphalangism.

Similarity: Belongs to the noggin family.

Noggin reacts with mouse, rat.

OMIM: 184460; phenotype. [NCBI / EBI]
185800; phenotype. [NCBI / EBI]
186500; phenotype. [NCBI / EBI]
186570; phenotype. [NCBI / EBI]
602991; gene. [NCBI / EBI]

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PRODUCT INTERACTIONS:

Noggin interacts with BMP-7 Human, CHO, Protein (GenWay Catalog #: 18-001-30117).

Noggin interacts with BMP-7 Human, Protein (GenWay Catalog #: 18-001-30117).

Noggin interacts with BMP-7, Protein (GenWay Catalog #: 18-001-30117).

Noggin interacts with BMP-7, IgG (GenWay Catalog #: 18-001-30117).

Noggin interacts with BMP7 (clone 4E7), IgG (GenWay Catalog #: 18-001-30117).

Noggin interacts with BMP7 (bone morphogenetic protein 7 (osteogenic protein 1)), IgG (GenWay Catalog #: 18-001-30117).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for NOG ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,, et al.
     Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
[2] Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,, et al.
     Direct Submission
[3] Valenzuela D.M., Economides A.N., Rojas E., Lamb T.M., Nunez L., Jones P., Ip N.Y., Espinosa R. III, Brannan C.I., Gilbert D.J., et al.
     Identification of mammalian noggin and its expression in the adult nervous system.
[4] Gong Y., Krakow D., Marcelino J., Wilkin D., Chitayat D., Babul-Hirji R., Hudgins L., Cremers C.W., Cremers F.P.M., Brunner H.G., et al.
     Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis.
[5] Takahashi T., Takahashi I., Komatsu M., Sawaishi Y., Higashi K., Nishimura G., Saito H., Takada G.
     Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome.
[6] Dixon M.E., Armstrong P., Stevens D.B., Bamshad M.
     Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism.
[7] Brown D.J., Kim T.B., Petty E.M., Downs C.A., Martin D.M., Strouse P.J., Moroi S.E., Milunsky J.M., Lesperance M.M.
     Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin.
[8] Mangino M., Flex E., Digilio M.C., Giannotti A., Dallapiccola B.
     Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: NOG antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of NOG antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about NOG antibody, all related information, articles, resources about NOG antibody are being stored on our online database. Let us know if you have questions regarding this product.

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