|
|
| CD41 Antibody, Mouse Monoclonal Antibody |
 |
|
|
 |
| Catalog Number: 20-783-310679 |
|
|
|
| Related Product Names:
|
-
CD41 antibody; CD41; GP2B; ITGAB; CD41
- MOUSE ANTI HUMAN CD41; Integrin alpha-IIb |
|
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
|
|
| Gene Name: CD41 |
Gene Name Synonym: GP2B; ITGAB |
Gi #:
N/A |
NCBI Acc #:
NP_000410.2 |
Swiss Prot Acc #:
P08514 |
Length (aa): N/A |
Mol. Weight (Da): 113391 |
Chrom Location: N/A |
|
|
 Specificity: CD41
NCBI Gene ID: 3674
Isotype: Specificity: CD41
Clone: PM6/248
Immunogen: Human platelet plasma membrane
Fusion Partner: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Preservative Stabilisers:
Suggested Dilution: Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood
Source/Host: Mouse
Clonality: Monoclonal
Crossreactivity: Target Species: Human
Reacts with: Baboon N.B.
Format: Purified
Storage: Store at +4 degree C or at -20 degree C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Stability: 18 months from date of despatch.
Shipping: Products may be shipped on ice pack or dry ice. |
|
| APPLICATIONS for CD41 ANTIBODY: |
| FACS/FC: Tested |
|
|
|
|
| CD41 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for CD41 antibody: CD41; GP2B; ITGAB; MOUSE ANTI HUMAN CD41; Integrin alpha-IIb
Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3.
Subcellular Location: Membrane; Single-pass type I membrane protein.
Tissue Specificity: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Polymorphism: Position 874 is associated with platelet-specific alloantigen HPA-3/BAK/LEK. HPA-3A/BAK(A)/LEK(A) has Ile-874 and HPA-3B/BAK(B)/LEK(B) has Ser-874. HPA-3B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP).
Disease: Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. This autosomal recessive disorder is the most common inherited disease of platelets. GT is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
Similarity: Belongs to the integrin alpha chain family.
Similarity: Contains 7 FG-GAP repeats.
CD41 reacts with target species: human
reacts with: baboon n.b..
OMIM: 273800; phenotype. [NCBI / EBI]
607759; gene. [NCBI / EBI]
Pathways:
KEGG pathway: ECM-receptor interaction 04512
KEGG pathway: Focal adhesion 04510
KEGG pathway: Hematopoietic cell lineage 04640
KEGG pathway: Regulation of actin cytoskeleton 04810
KEGG pathway: Small cell lung cancer 05222
Reactome Event:Hemostasis 109582
Products similar to CD41 antibody:
IgG
 Integrin alpha 2b + beta 3 [237], IgG
Integrin alpha 2b + beta 3 [290.5C10], IgG
Integrin alpha 2b + beta 3 [P256], IgG
CD41/CD61, IgG
CD41, IgG
|
|
|
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
|
|
| BACKGROUND
REFERENCES for CD41 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| 1. Hornby. E.J. et al. (1991) Activation of human platelets by exposure to a monoclonal. PM6/248. to glycoprotein IIb-IIIa. Br. J. Haematol. 79: 277-285.2. Michelson. A.D. et al. (1995) A panel of platelet mAb for the study of haemostasis and thrombosis in baboons. Leucocyte Typing V. Oxford University Press p 1230-1231. |
|
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: CD41 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of CD41 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CD41 antibody, all related information, articles, resources about CD41 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
|
|
|
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
|
|
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
|
|
