Snca antibody, alpha-Synuclein (clone 5C2) Antibody, Mouse Monoclonal Antibody

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alpha-Synuclein (clone 5C2) Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-002-35023

Buy Snca antibody -

Volume:

Related Product Names:

- Snca antibody; Snca; Syn; alpha-Synuclein (clone 5C2)
- Monoclonal anti alpha-Synuclein (61-95 aa) antibody (clone 5C2); Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; Alpha-synuclein

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Snca	Gene Name Synonym: Syn
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: O55042
Length (aa): N/A	Mol. Weight (Da): 14485	Chrom Location: N/A

Isotype: Mouse IgG1 heavy chain and kappa light chain

Clone Number: Anti-human alpha-Synuclein (61-95 aa) mAb, clone 5C2, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein. This antibody specifically recognizes alpha-synuclein only, particularly the NAC domain of alpha-synuclein.

Immunogen: Recombinant human alpha-synuclein (1-140) purified from E. coli

Concentration: 1mg/ml

Usage: The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should titrate the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:2,000. This antibody(5C2) has the specificity against the NAC domain of alpha-synuclein. Recommended starting dilution is 1:1,000.

Source/Host: Mouse

Clonality: Monoclonal

Crossreactivity: Human

Format: Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Storage: The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. Can be stored at 4C for up to one month, but store at -20C for long term storage. Avoid repeated freezing and thawing cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for SNCA ANTIBODY:

ELISA, WB: Tested

TESTING: (secondary reagents and protocols )

WB ( anti-Snca )

Snca antibody image
Snca

SNCA ANTIBODY TARGET DESCRIPTION:

Synonym Names for Snca antibody: Snca; Syn; Monoclonal anti alpha-Synuclein (61-95 aa) antibody (clone 5C2); Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; Alpha-synuclein

alpha-synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-Abeta component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.

Function: May be involved in the regulation of dopamine release and transport.

Subunit: Interacts with UCHL1 (By similarity).

Subcellular Location: Cytoplasm (By similarity).

Ptm: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress (By similarity).

Ptm: Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).

Similarity: Belongs to the synuclein family.

alpha-Synuclein (clone 5C2) reacts with human.

Products similar to Snca antibody:

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SYNGAP1, IgG

gamma-Synuclein, IgG

Synaptotagmin [ASV30], IgG

Peptide

Alpha Synuclein C-terminal Peptide, Peptide

alpha-Synuclein E46K, Protein

alpha-Synuclein, Protein

alpha-Synuclein A30P/A53T, Protein

alpha-Synuclein, Protein

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for SNCA ANTIBODY:

Background references for antibody target are not specific to GenWay products

1. Jakes, R., et al. (1994) FEBS lett. 345, 27-32
1. Ueda, K., et al. (1993) Proc. Natl.Acad. Sci. USA 90, 11282-11286
1. Kim, J. (1997) Molecules and Cells 7, 78-83
1. Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344, 325-334.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Snca antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Snca antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Snca antibody, all related information, articles, resources about Snca antibody are being stored on our online database. Let us know if you have questions regarding this product.

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