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| GLIS2 (GLIS family zinc finger 2) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-003-42012 |
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| Related Product Names:
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GLIS2 antibody; GLIS2; HGNC:29450; GLIS2 (GLIS family zinc finger 2)
- GLI-similar 2; Neuronal Krueppel-like protein; GLIS family zinc finger 2; Zinc finger protein GLIS2 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: GLIS2 |
Gene Name Synonym: HGNC:29450 |
Gi #:
110431364 |
NCBI Acc #:
NP_115964.2 |
Swiss Prot Acc #:
Q9BZE0 |
Length (aa): 524 |
Mol. Weight (Da): 55705 |
Chrom Location: N/A |
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 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human GLIS2.
ELISA Titre: 1:312500
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.
Clonality: Polyclonal
Crossreactivity: Human
Format: Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for GLIS2 ANTIBODY: |
| WB: Tested |
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| GLIS2 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for GLIS2 antibody: GLIS2; HGNC:29450; GLI-similar 2; Neuronal Krueppel-like protein; GLIS family zinc finger 2; Zinc finger protein GLIS2
Members of the Kruppel-like zinc finger protein family. such as GLIS2. function as activators and/or repressors of gene transcription.
Function: Can act either as a transcription repressor or as a transcription activator, depending on the cell context. Represses the transcriptional activation mediated by CTNNB1 in the Wnt pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).
Subunit: Interacts with CTBP1 and HDAC3. Interacts with CTNNB1 (By similarity). Interacts with CTNND1.
Subcellular Location: Nucleus speckle (By similarity). Cytoplasm (By similarity).
Tissue Specificity: Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
Domain: The C2H2-type zinc finger 1 has a major repressor function and is required for CTNNB1 binding (By similarity).
Ptm: C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase (By similarity).
Disease: Defects in GLIS2 are the cause of nephronophthisis type 7 (NPHP7) [MIM:611498]. NPHP7 is an autosomal recessive disorder resulting in end-stage renal disease during childhood or adolescence. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
Similarity: Belongs to the GLI C2H2-type zinc-finger protein family.
Similarity: Contains 5 C2H2-type zinc fingers.
Summary: Members of the Kruppel-like zinc finger protein family, such as GLIS2, function as activators and/or repressors of gene transcription.[supplied by OMIM].
GLIS2 (GLIS family zinc finger 2) reacts with human.
OMIM: 608539; gene. [NCBI / EBI]
611498; phenotype. [NCBI / EBI]
Products similar to GLIS2 antibody:
IgG
 GLIS2 (GLIS family zinc finger 2), IgG
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for GLIS2 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Zhang.F.. et al.. (2002) J. Biol. Chem. 277 (12). 10139-10149. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: GLIS2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of GLIS2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about GLIS2 antibody, all related information, articles, resources about GLIS2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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