FGD1 antibody, FGD1 (FYVE. RhoGEF and PH domain containing 1 (faciogenital dysplasia)) Antibody, Rabbit Polyclonal Antibody

Alphabetical Listing of Primary Antibodies:	\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

FGD1 (FYVE. RhoGEF and PH domain containing 1 (faciogenital dysplasia)) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-42077

Buy FGD1 antibody -

Size:

Trial Size Available. Please expect delivery of trial size products to be 4 weeks.

Related Product Names:

- FGD1 antibody; FGD1; RP1-112K5.1, AAS, FGDY, ZFYVE3; FGD1 (FYVE. RhoGEF and PH domain containing 1 (faciogenital dysplasia))
- Faciogenital dysplasia 1 protein; Zinc finger FYVE domain-containing protein 3; Rho/Rac guanine nucleotide exchange factor FGD1; Rho/Rac GEF; Faciogenital dysplasia protein; FYVE, RhoGEF and PH domain-containing protein 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: FGD1	Gene Name Synonym: RP1-112K5.1, AAS, FGDY, ZFYVE3
Gi #: 24797153	NCBI Acc #: NP_004454.2	Swiss Prot Acc #: P98174
Length (aa): 961	Mol. Weight (Da): 106561	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human FGD1.

ELISA Titre: 1:312500

Category: Signaling Intermediates

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 2.0 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for FGD1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-FGD1 )

FGD1 antibody WB image
FGD1

FGD1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for FGD1 antibody: FGD1; RP1-112K5.1, AAS, FGDY, ZFYVE3; Faciogenital dysplasia 1 protein; Zinc finger FYVE domain-containing protein 3; Rho/Rac guanine nucleotide exchange factor FGD1; Rho/Rac GEF; Faciogenital dysplasia protein; FYVE, RhoGEF and PH domain-containing protein 1

FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade

Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.

Subunit: Interacts with DBNL/ABP1 and CTTN. May interact with CCPG1 (By similarity). Binds CDC42.

Subcellular Location: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Associated with membrane ruffles and lamellipodia (By similarity).

Tissue Specificity: Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.

Domain: The DH domain is involved in interaction with CCPG1 (By similarity).

Disease: Defects in FGD1 are the cause of Aarskog-Scott syndrome (AAS) [MIM:305400]. This faciogenital dysplasia is a rare multisystemic disorder characterized by disproportionately short stature, and by facial, skeletal, and urogenital anomalies.

Disease: Defects in FGD1 are a cause of non-syndromal X-linked mental retardation.

Similarity: Contains 1 DH (DBL-homology) domain.

Similarity: Contains 1 FYVE-type zinc finger.

Similarity: Contains 2 PH domains.

Summary: FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.

FGD1 (FYVE. RhoGEF and PH domain containing 1 (faciogenital dysplasia)) reacts with human.

OMIM: 300546; gene. [NCBI / EBI]
305400; phenotype. [NCBI / EBI]

Products similar to FGD1 antibody:

IgG

FGD1, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for FGD1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Lebel.R.R.. et al.. (2002) Clin. Genet. 61 (2). 139-145.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: FGD1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of FGD1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FGD1 antibody, all related information, articles, resources about FGD1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved