CSEN antibody, CSEN Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

CSEN Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-42115

Buy CSEN antibody -

Size:

Trial Size Available. Please expect delivery of trial size products to be 4 weeks.

Related Product Names:

- CSEN antibody; CSEN; DREAM, KCHIP3, KCNIP3, MGC18289; CSEN
- Kv channel-interacting protein 3; KChIP3; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel interacting protein 3 isoform 1; Calsenilin

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CSEN	Gene Name Synonym: DREAM, KCHIP3, KCNIP3, MGC18289
Gi #: 7305199	NCBI Acc #: NP_038462.1	Swiss Prot Acc #: Q9Y2W7
Length (aa): 256	Mol. Weight (Da): 29231	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human CSEN.

ELISA Titre: 1:12500

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 2.0 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CSEN ANTIBODY:

IHC-P. WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

IHC: ( anti-CSEN )

CSEN antibody IHC image
CSEN

WB: ( anti-CSEN )

CSEN antibody WB image
CSEN

CSEN ANTIBODY TARGET DESCRIPTION:

Synonym Names for CSEN antibody: CSEN; DREAM, KCHIP3, KCNIP3, MGC18289; Kv channel-interacting protein 3; KChIP3; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel interacting protein 3 isoform 1; Calsenilin

CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs). which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-li

Function: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).

Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell surface.

Function: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.

Subunit: Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Component of heteromultimeric potassium channels. Interacts with KCND2 and KCND3 (By similarity). Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1.

Subcellular Location: Cytoplasm. Cell membrane; Lipid-anchor (By similarity). Endoplasmic reticulum. Golgi apparatus. Nucleus (Probable). Note=Also membrane-bound, associated with the plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi.

Tissue Specificity: Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.

Ptm: Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity).

Ptm: Proteolytically cleaved by caspase-3.

Similarity: Belongs to the recoverin family.

Similarity: Contains 4 EF-hand domains.

Summary: This protein is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.

CSEN reacts with human.

OMIM: 604662; gene. [NCBI / EBI]

Products similar to CSEN antibody:

IgG

Calsenilin, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for CSEN ANTIBODY:

Background references for antibody target are not specific to GenWay products

Zaidi.N.F.. et al.. (2004) J. Neurochem. 89 (3). 593-601.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: CSEN antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CSEN antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CSEN antibody, all related information, articles, resources about CSEN antibody are being stored on our online database. Let us know if you have questions regarding this product.

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