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| JMJD1A (jumonji domain containing 1A) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-003-42309 |
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| Related Product Names:
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JMJD1A antibody; JMJD1A; DKFZp686A24246, DKFZp686P07111, JMJD1, KIAA0742, TSGA; JMJD1A (jumonji domain containing 1A)
- EC 1.14.11.-; Jumonji domain-containing protein 1A; Jumonji domain containing 1A; JmjC domain-containing histone demethylation protein 2A |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: JMJD1A |
Gene Name Synonym: DKFZp686A24246, DKFZp686P07111, JMJD1, KIAA0742, TSGA |
Gi #:
20357522 |
NCBI Acc #:
NP_060903.2 |
Swiss Prot Acc #:
Q53S72 |
Length (aa): 1321 |
Mol. Weight (Da): 147327 |
Chrom Location: N/A |
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 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human JMJD1A.
ELISA Titre: 1:62500
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit IgG purified by protein A chromatography.
Clonality: Polyclonal
Crossreactivity: Human
Format: Suggested dilution at 1.0 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for JMJD1A ANTIBODY: |
| IHC-P. WB: Tested |
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| JMJD1A ANTIBODY TARGET DESCRIPTION: |
Synonym Names for JMJD1A antibody: JMJD1A; DKFZp686A24246, DKFZp686P07111, JMJD1, KIAA0742, TSGA; EC 1.14.11.-; Jumonji domain-containing protein 1A; Jumonji domain containing 1A; JmjC domain-containing histone demethylation protein 2A
Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.
Cofactor: Binds 1 Fe(2+) ion per subunit.
Subcellular Location: Nucleus (Probable).
Domain: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.
Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity).
Similarity: Belongs to the JHDM2 histone demethylase family.
Similarity: Contains 1 JmjC domain.
Summary: This protein is a zinc finger protein that contains a jumonji domain.
JMJD1A (jumonji domain containing 1A) reacts with human.
OMIM: 611512; gene. [NCBI / EBI]
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for JMJD1A ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Katoh.M. et al.. (2003) Int. J. Mol. Med. 12 (5). 817-821. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: JMJD1A antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of JMJD1A antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about JMJD1A antibody, all related information, articles, resources about JMJD1A antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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