WHSC1 antibody, WHSC1 (Wolf-Hirschhorn syndrome candidate 1) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

WHSC1 (Wolf-Hirschhorn syndrome candidate 1) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-42383

Buy WHSC1 antibody -

Size:

Trial Size Available. Please expect delivery of trial size products to be 4 weeks.

Related Product Names:

- WHSC1 antibody; WHSC1; KIAA1090, MMSET, NSD2, REIIBP, TRX5; WHSC1 (Wolf-Hirschhorn syndrome candidate 1)
- EC 2.1.1.43; Nuclear SET domain-containing protein 2; Wolf-Hirschhorn syndrome candidate 1 protein; Multiple myeloma SET domain-containing protein; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein isoform 2; Probable histone-lysine N-methyltransferase NSD2

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: WHSC1	Gene Name Synonym: KIAA1090, MMSET, NSD2, REIIBP, TRX5
Gi #: 19913346	NCBI Acc #: NP_055734.1	Swiss Prot Acc #: O96031
Length (aa): 802	Mol. Weight (Da): 152258	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human WHSC1.

ELISA Titre: 1:12500

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for WHSC1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-WHSC1 )

WHSC1 antibody WB image
WHSC1

WHSC1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for WHSC1 antibody: WHSC1; KIAA1090, MMSET, NSD2, REIIBP, TRX5; EC 2.1.1.43; Nuclear SET domain-containing protein 2; Wolf-Hirschhorn syndrome candidate 1 protein; Multiple myeloma SET domain-containing protein; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein isoform 2; Probable histone-lysine N-methyltransferase NSD2

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain. an HMG box. a SET domain. and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malform

Function: Probable histone methyltransferase (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription.

Catalytic Activity: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine.

Subcellular Location: Nucleus.

Subcellular Location: Isoform 4: Cytoplasm.

Tissue Specificity: Widely expressed.

Ptm: Phosphorylated upon DNA damage, probably by ATM or ATR.

Disease: A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.

Disease: A chromosomal aberration involving WHSC1 is a cause of Wolf-Hirschhorn syndrome (WHS) [MIM:194190]. WHS is caused by sub-telomeric deletions in the short arm of chromosome 4. WHS is characterized by profound mental retardation, heart defects, and facial clefting. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.

Similarity: Belongs to the histone-lysine methyltransferase family. SET2 subfamily.

Similarity: Contains 1 AWS domain.

Similarity: Contains 1 HMG box DNA-binding domain.

Similarity: Contains 4 PHD-type zinc fingers.

Similarity: Contains 1 post-SET domain.

Similarity: Contains 2 PWWP domains.

Similarity: Contains 1 SET domain.

Summary: This protein is a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This protein maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. This protein contains 25 exons. Alternative splicing of this gene generates nine transcript variants, which encode four different isoforms.

WHSC1 (Wolf-Hirschhorn syndrome candidate 1) reacts with human.

OMIM: 194190; phenotype. [NCBI / EBI]
602952; gene. [NCBI / EBI]

Products similar to WHSC1 antibody:

IgG

WHSC1 / MMSET, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for WHSC1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Santra.M.. et al.. (2003) Blood 101 (6). 2374-2376.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: WHSC1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of WHSC1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about WHSC1 antibody, all related information, articles, resources about WHSC1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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