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| UBE2N (ubiquitin-conjugating enzyme E2N (UBC13 homolog. yeast)) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-003-42472 |
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| Related Product Names:
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UBE2N antibody; UBE2N; MGC8489, UBC13, UbcH-ben; UBE2N (ubiquitin-conjugating enzyme E2N (UBC13 homolog. yeast))
- EC 6.3.2.19; Ubiquitin-protein ligase N; Ubiquitin carrier protein N; Ubc13; Bendless-like ubiquitin-conjugating enzyme; Ubiquitin-conjugating enzyme E2N; Ubiquitin-conjugating enzyme E2 N |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: UBE2N |
Gene Name Synonym: MGC8489, UBC13, UbcH-ben |
Gi #:
4507793 |
NCBI Acc #:
NP_003339.1 |
Swiss Prot Acc #:
P61088 |
Length (aa): 152 |
Mol. Weight (Da): 17138 |
Chrom Location: N/A |
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 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human UBE2N.
ELISA Titre: 1:312500
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit IgG purified by protein A chromatography.
Clonality: Polyclonal
Crossreactivity: Human
Format: Suggested dilution at 1.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for UBE2N ANTIBODY: |
| WB: Tested |
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| UBE2N ANTIBODY TARGET DESCRIPTION: |
Synonym Names for UBE2N antibody: UBE2N; MGC8489, UBC13, UbcH-ben; EC 6.3.2.19; Ubiquitin-protein ligase N; Ubiquitin carrier protein N; Ubc13; Bendless-like ubiquitin-conjugating enzyme; Ubiquitin-conjugating enzyme E2N; Ubiquitin-conjugating enzyme E2 N
UBE2N encodes a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three cla
Function: The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligase SHPRH in the poly-ubiquitination of PCNA 'Lys-164' upon genotoxic stress, which is required for DNA repair.
Catalytic Activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway: Protein degradation; protein ubiquitination.
Subunit: Heterodimer with UBE2V2. Interacts with RNF8 and SHPRH.
Ptm: Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V2.
Similarity: Belongs to the ubiquitin-conjugating enzyme family.
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.
UBE2N (ubiquitin-conjugating enzyme E2N (UBC13 homolog. yeast)) reacts with human.
OMIM: 603679; gene. [NCBI / EBI]
Products similar to UBE2N antibody:
IgG
 UBC13, IgG
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| PRODUCT INTERACTIONS: |
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for UBE2N ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Bothos.J.. et al.. (2003) Oncogene 22 (46). 7101-7107. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: UBE2N antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of UBE2N antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about UBE2N antibody, all related information, articles, resources about UBE2N antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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