NSEP1 antibody, NSEP1 Antibody, Rabbit Polyclonal Antibody

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NSEP1 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-42521

Buy NSEP1 antibody -

Size:

Related Product Names:

- NSEP1 antibody; NSEP1; BP-8, CSDB, DBPB, MDR-NF1, MGC110976, NSEP-1, YB-1, YB1, YBX1; NSEP1
- Y-box-binding protein 1; Y-box transcription factor; YB-1; CCAAT-binding transcription factor I subunit A; CBF-A; Enhancer factor I subunit A; EFI-A; DNA-binding protein B; DBPB; Nuclease sensitive element binding protein 1; Nuclease-sensitive element-binding protein 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: NSEP1	Gene Name Synonym: BP-8, CSDB, DBPB, MDR-NF1, MGC110976, NSEP-1, YB-1, YB1, YBX1
Gi #: 34098946	NCBI Acc #: NP_004550.2	Swiss Prot Acc #: Q5FVF0
Length (aa): 324	Mol. Weight (Da): 35924	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human NSEP1.

ELISA Titre: 1:62500

Category: Transcription Factor Antibodies

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for NSEP1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-NSEP1 )

NSEP1 antibody WB image
NSEP1

NSEP1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for NSEP1 antibody: NSEP1; BP-8, CSDB, DBPB, MDR-NF1, MGC110976, NSEP-1, YB-1, YB1, YBX1; Y-box-binding protein 1; Y-box transcription factor; YB-1; CCAAT-binding transcription factor I subunit A; CBF-A; Enhancer factor I subunit A; EFI-A; DNA-binding protein B; DBPB; Nuclease sensitive element binding protein 1; Nuclease-sensitive element-binding protein 1

NSEP1 is a cell cycle stage-specific transcription factor important for cell proliferation. NSEP1 encodes a protein that correlates with P-glycoprotein expression in human breast carcinoma.

Function: Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair.

Subunit: Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, SFRS9, THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP.

Subcellular Location: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus.

Ptm: In the absence of phosphorylation the protein is retained in the cytoplasm.

Ptm: Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus (By similarity).

Similarity: Contains 1 CSD (cold-shock) domain.

NSEP1 reacts with human.

OMIM: 154030; gene. [NCBI / EBI]

PRODUCT INTERACTIONS:

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for NSEP1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Kim.S.Y.. et al.. (2004) Virology 327 (1). 60-69.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: NSEP1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of NSEP1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about NSEP1 antibody, all related information, articles, resources about NSEP1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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