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| SUV420H1 (suppressor of variegation 4-20 homolog 1 (Drosophila)) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-003-42553 |
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| Related Product Names:
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SUV420H1 antibody; SUV420H1; CGI-85, MGC118906, MGC118909, MGC21161, MGC703; SUV420H1 (suppressor of variegation 4-20 homolog 1 (Drosophila))
- EC 2.1.1.43; Suppressor of variegation 4-20 homolog 1; Suv4-20h1; Su(var)4-20 homolog 1; Lysine N-methyltransferase 5B; SUV420H1 protein; Histone-lysine N-methyltransferase SUV420H1 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: SUV420H1 |
Gene Name Synonym: CGI-85, MGC118906, MGC118909, MGC21161, MGC703 |
Gi #:
66990066 |
NCBI Acc #:
AAH98121.1 |
Swiss Prot Acc #:
Q4V775 |
Length (aa): 471 |
Mol. Weight (Da): 99188 |
Chrom Location: N/A |
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 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human SUV420H1.
ELISA Titre: 1:1562500
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit IgG purified by protein A chromatography.
Clonality: Polyclonal
Crossreactivity: Human
Format: Suggested dilution at 1.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for SUV420H1 ANTIBODY: |
| WB: Tested |
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| SUV420H1 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for SUV420H1 antibody: SUV420H1; CGI-85, MGC118906, MGC118909, MGC21161, MGC703; EC 2.1.1.43; Suppressor of variegation 4-20 homolog 1; Suv4-20h1; Su(var)4-20 homolog 1; Lysine N-methyltransferase 5B; SUV420H1 protein; Histone-lysine N-methyltransferase SUV420H1
SUV420H1 is a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this
Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).
Catalytic Activity: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine.
Subunit: Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity).
Subcellular Location: Nucleus. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
Induction: Strongly down-regulated in breast cancer cells.
Similarity: Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily.
Similarity: Contains 1 SET domain.
SUV420H1 (suppressor of variegation 4-20 homolog 1 (Drosophila)) reacts with human.
OMIM: 610881; gene. [NCBI / EBI]
Products similar to SUV420H1 antibody:
IgG
 SUV420H1 (suppressor of variegation 4-20 homolog 1 (Drosophila)), IgG
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| PRODUCT INTERACTIONS: |
SUV420H1 (suppressor of variegation 4-20 homolog 1 (Drosophila)) interacts with YWHAQ, IgG (GenWay Catalog #: 18-003-42553).
SUV420H1 (suppressor of variegation 4-20 homolog 1 (Drosophila)) interacts with 14-3-3 Tau Human, Protein (GenWay Catalog #: 18-003-42553).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for SUV420H1 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Strausberg.R.L.. et al.. (2002) Proc. Natl. Acad. Sci. U.S.A. 99 (26). 16899-16903. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: SUV420H1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of SUV420H1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SUV420H1 antibody, all related information, articles, resources about SUV420H1 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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