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| IBSP (integrin-binding sialoprotein (bone sialoprotein. bone sialoprotein II)) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-003-42820 |
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| Related Product Names:
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IBSP antibody; IBSP; BNSP, BSP, BSP-II, SP-II; IBSP (integrin-binding sialoprotein (bone sialoprotein. bone sialoprotein II))
- Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein; Integrin-binding sialoprotein; Bone sialoprotein 2 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: IBSP |
Gene Name Synonym: BNSP, BSP, BSP-II, SP-II |
Gi #:
167466187 |
NCBI Acc #:
NP_004958.2 |
Swiss Prot Acc #:
P21815 |
Length (aa): 317 |
Mol. Weight (Da): 35018 |
Chrom Location: N/A |
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 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human IBSP.
ELISA Titre: 1:62500
Category: Signal Protein
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit IgG purified by protein A chromatography.
Clonality: Polyclonal
Crossreactivity: Human
Format: Suggested dilution at 1.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for IBSP ANTIBODY: |
| WB: Tested |
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| IBSP ANTIBODY TARGET DESCRIPTION: |
Synonym Names for IBSP antibody: IBSP; BNSP, BSP, BSP-II, SP-II; Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein; Integrin-binding sialoprotein; Bone sialoprotein 2
The protein encoded by the IBSP gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types. including hypertrophic chondrocytes.
Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Subcellular Location: Secreted.
Ptm: N-glycosylated; glycans consist of sialated and core-fucosylated bi-, tri- and tetraantennary chains.
Ptm: O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.
Ptm: Sulfated on either Tyr-313 or Tyr-314.
Miscellaneous: It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.
Summary: The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
IBSP (integrin-binding sialoprotein (bone sialoprotein. bone sialoprotein II)) reacts with human.
OMIM: 147563; gene. [NCBI / EBI]
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for IBSP ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Barnes.G.L.. et al.. (2003) Cancer Res. 63 (10). 2631-2637. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: IBSP antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of IBSP antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about IBSP antibody, all related information, articles, resources about IBSP antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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