APP antibody, APP (amyloid beta (A4) precursor protein (peptidase nexin-II. Alzheimer disease)) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

APP (amyloid beta (A4) precursor protein (peptidase nexin-II. Alzheimer disease)) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-42859

Buy APP antibody -

Size:

Related Product Names:

- APP antibody; APP; AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2; APP (amyloid beta (A4) precursor protein (peptidase nexin-II. Alzheimer disease))
- Amyloid beta A4 protein, isoform c; N/A

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: APP	Gene Name Synonym: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Gi #: 41406057	NCBI Acc #: NP_958817.1	Swiss Prot Acc #: N/A
Length (aa): 695	Mol. Weight (Da): 44 kDa	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human APP.

Western Blot: Suggested dilution at 1.0 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Protein Size: 40

Category: Tumor Suppressor Genes & Apoptosis

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by Protein G/A affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for APP ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-APP )

APP antibody WB image
APP

APP ANTIBODY TARGET DESCRIPTION:

Synonym Names for APP antibody: APP; AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2; Amyloid beta A4 protein, isoform c; N/A

Amyloid-. protein is thought to play a causal role in the development of Alzheimer`s disease. Amyloid-. protein is variably cleaved at the C-terminus to form peptides 39-43 amino acids in length. Antibody recognizes only 1-40 and not the amyloid-. precursor protein

Summary: This protein is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Summary: This protein is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq].

APP (amyloid beta (A4) precursor protein (peptidase nexin-II. Alzheimer disease)) reacts with human.

OMIM: NCBI [104760]

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Peptide

beta-Amyloid (1-40), Peptide

beta-Amyloid (1-42) Human, Peptide

Amyloid Precursor Protein C-term Peptide, Peptide

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F-actin capping protein alpha-1 subunit, Protein

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for APP ANTIBODY:

Background references for antibody target are not specific to GenWay products

Selko. D.J.. et al. (1990) Scince 248:1058.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: APP antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of APP antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about APP antibody, all related information, articles, resources about APP antibody are being stored on our online database. Let us know if you have questions regarding this product.

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