CAV3 antibody, CAV3 (caveolin 3) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

CAV3 (caveolin 3) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-42926

Buy CAV3 antibody -

Size:

Trial Size Available. Please expect delivery of trial size products to be 4 weeks.

Related Product Names:

- CAV3 antibody; CAV3; LGMD1C, MGC126100, MGC126101, MGC126129, VIP-21, VIP21; CAV3 (caveolin 3)
- M-caveolin; Caveolin 3; Caveolin-3

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CAV3	Gene Name Synonym: LGMD1C, MGC126100, MGC126101, MGC126129, VIP-21, VIP21
Gi #: 4502589	NCBI Acc #: NP_001225.1	Swiss Prot Acc #: P56539
Length (aa): 151	Mol. Weight (Da): 17259	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CAV3.

ELISA Titre: 1:12500

Category: Membrane Protein

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CAV3 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-CAV3 )

CAV3 antibody WB image
CAV3

CAV3 ANTIBODY TARGET DESCRIPTION:

Synonym Names for CAV3 antibody: CAV3; LGMD1C, MGC126100, MGC126101, MGC126129, VIP-21, VIP21; M-caveolin; Caveolin 3; Caveolin-3

CAV3 is a caveolin family member. which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules.

Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels.

Subunit: Homooligomer. Interacts with DLG1 and KCNA5 and forms a ternary complex (By similarity).

Subcellular Location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell membrane, caveola; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Membrane protein of protein of caveolae. Potential hairpin-like structure in the membrane (By similarity).

Tissue Specificity: Expressed predominantly in muscle.

Disease: Defects in CAV3 are the cause of limb-girdle muscular dystrophy type 1C (LGMD1C) [MIM:607801]. LGMD1C is a myopathy characterized by calf hypertrophy and mild to moderate proximal muscle weakness. LGMD1C inheritance can be autosomal dominant or recessive.

Disease: Defects in CAV3 are a cause of hyperCKmia [MIM:123320]. It is a disease characterized by persistent elevated levels of serum creatine kinase without muscle weakness.

Disease: Defects in CAV3 are a cause of rippling muscle disease (RMD) [MIM:606072]. RMD is rare a disorder characterized by mechanically triggered contractions of skeletal muscle. In RMD, mechanical stimulation leads to electrically silent muscle contractions that spread to neighboring fibers that cause visible ripples to move over the muscle.

Disease: Defects in CAV3 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Hypertrophic cardiomyopathy is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. CMH is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Similarity: Belongs to the caveolin family.

Summary: This protein is a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.

CAV3 (caveolin 3) reacts with human.

OMIM: 123320; phenotype. [NCBI / EBI]
192600; phenotype. [NCBI / EBI]
601253; gene+phenotype. [NCBI / EBI]
606072; phenotype. [NCBI / EBI]
607801; phenotype. [NCBI / EBI]

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for CAV3 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Alias.L.. et al.. (2004) Neuromuscul. Disord. 14 (5). 321-324.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: CAV3 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CAV3 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CAV3 antibody, all related information, articles, resources about CAV3 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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