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| GABRP (gamma-aminobutyric acid (GABA) A receptor. pi) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-003-42955 |
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| Related Product Names:
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GABRP antibody; GABRP; GABRP (gamma-aminobutyric acid (GABA) A receptor. pi)
- GABA(A) receptor subunit pi; Gamma-aminobutyric acid (GABA) A receptor, pi; Gamma-aminobutyric acid receptor subunit pi |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: GABRP |
Gene Name Synonym: N/A |
Gi #:
7657106 |
NCBI Acc #:
NP_055026.1 |
Swiss Prot Acc #:
O00591 |
Length (aa): 440 |
Mol. Weight (Da): 50640 |
Chrom Location: N/A |
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 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human GABRP.
ELISA Titre: 1:1562500
Category: Neurobiology
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.
Clonality: Polyclonal
Crossreactivity: Human
Format: Suggested dilution at 0.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for GABRP ANTIBODY: |
| WB: Tested |
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| GABRP ANTIBODY TARGET DESCRIPTION: |
Synonym Names for GABRP antibody: GABRP; GABA(A) receptor subunit pi; Gamma-aminobutyric acid (GABA) A receptor, pi; Gamma-aminobutyric acid receptor subunit pi
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded GABRP is expressed in several non-neuronal tissues including the
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex.
Subcellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity: Most abundant in the uterus, also expressed in lung, thymus and prostate.
Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family [view classification].
Summary: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
GABRP (gamma-aminobutyric acid (GABA) A receptor. pi) reacts with human.
OMIM: 602729; gene. [NCBI / EBI]
Products similar to GABRP antibody:
IgG
 GABRP, IgG
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for GABRP ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Neelands.T.R. (1999) Mol. Pharmacol. 56 (3). 598-610. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: GABRP antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of GABRP antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about GABRP antibody, all related information, articles, resources about GABRP antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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