Alphabetical Listing of Primary Antibodies:
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5-9
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A
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B
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C
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D
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E
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F
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G
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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U
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Y
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Alphabetical Listing of Proteins:
f
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
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ELISA Kits
GRIA2 (glutamate receptor. ionotropic. AMPA 2) Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-003-42968
Buy GRIA2 antibody -
Size:
0.1 mg ($255.00)
Related Product Names:
- GRIA2 antibody; GRIA2; GLUR2, GLURB, HBGR2; GRIA2 (glutamate receptor. ionotropic. AMPA 2)
- GluR-2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; AMPA-selective glutamate receptor 2; Glutamate receptor, ionotropic, AMPA 2 isoform 1; Glutamate receptor 2
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
GRIA2
Gene Name Synonym:
GLUR2, GLURB, HBGR2
Gi #:
74275354
NCBI Acc #:
NP_000817.2
Swiss Prot Acc #:
P42262
Length (aa):
883
Mol. Weight (Da):
98821
Chrom Location:
N/A
Antigen Specificity:
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human GRIA2.
ELISA Titre:
1:62500
Category:
Signaling Intermediates
Note:
Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host:
Rabbit
Clonality:
Polyclonal
Crossreactivity:
Human
Format:
Suggested dilution at 1 .g/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage:
Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability:
Note: Avoid repeat freeze-thaw cycles.
Shipping:
Products may be shipped on ice pack or dry ice.
TESTING: (
secondary reagents
and
protocols
[IHC Protocol]
)
Not Available
GRIA2 ANTIBODY TARGET DESCRIPTION:
Synonym Names for GRIA2 antibody:
GRIA2; GLUR2, GLURB, HBGR2; GluR-2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; AMPA-selective glutamate receptor 2; Glutamate receptor, ionotropic, AMPA 2 isoform 1; Glutamate receptor 2
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of GLU are mediated by a variety of receptors that are named according to their selective agonists. This re
Function:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
Subunit:
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity).
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Ptm:
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Rna Editing:
Modified_positions=607; Note=Partially edited. Fully edited in the brain. Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium whereas the unedited (Q) forms are highly permeable to divalent ions.
Miscellaneous:
The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10) family [view classification].
Summary:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This protein product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
GRIA2 (glutamate receptor. ionotropic. AMPA 2) reacts with human.
OMIM:
138247; gene. [
NCBI
/
EBI
]
Products similar to GRIA2 antibody:
IgG
GRIA2 (glutamate receptor. ionotropic. AMPA 2), IgG
Glutamate receptor 2, IgG
GluR2, IgG
Glutamate receptor 2, IgG
GLUTAMATE RECEPTOR 2, Protein
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for GRIA2 ANTIBODY:
Background references for antibody target are not specific to GenWay products
Sun. W.. et al.. (1994) NeuroReport 5:441-444.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
GRIA2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of GRIA2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about GRIA2 antibody, all related information, articles, resources about GRIA2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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