AREB6 antibody, AREB6 Antibody, Rabbit Polyclonal Antibody

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AREB6 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-43000

Buy AREB6 antibody -

Size:

Related Product Names:

- AREB6 antibody; AREB6; AREB6, BZP, NIL-2-A, NIL-2A, ZEB, ZEB1, ZFHEP, ZFHX1A; AREB6
- Transcription factor 8; NIL-2-A zinc finger protein; Negative regulator of IL2; Zinc finger E-box binding homeobox 1; Zinc finger E-box-binding homeobox 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: AREB6	Gene Name Synonym: AREB6, BZP, NIL-2-A, NIL-2A, ZEB, ZEB1, ZFHEP, ZFHX1A
Gi #: 28077091	NCBI Acc #: NP_110378.2	Swiss Prot Acc #: P37275
Length (aa): 1124	Mol. Weight (Da): 124074	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human AREB6.

ELISA Titre: 1:62500

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by Protein G/A affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 1 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols [IHC Protocol])

Not Available

AREB6 ANTIBODY TARGET DESCRIPTION:

Synonym Names for AREB6 antibody: AREB6; AREB6, BZP, NIL-2-A, NIL-2A, ZEB, ZEB1, ZFHEP, ZFHX1A; Transcription factor 8; NIL-2-A zinc finger protein; Negative regulator of IL2; Zinc finger E-box binding homeobox 1; Zinc finger E-box-binding homeobox 1

Transcription Factor AREB6 / transcription factor 8 /zinc finger homeodomain enhancer-binding protein inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter act

Function: Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type.

Subcellular Location: Nucleus.

Tissue Specificity: Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.

Disease: Defects in ZEB1 are the cause of posterior polymorphous corneal dystrophy type 3 (PPCD3) [MIM:609141]. Posterior polymorphous corneal dystrophy (PPCD) is a rare disease involving metaplasia and overgrowth of corneal endothelial cells. In patients with PPCD, these cells manifest in an epithelial morphology and gene expression pattern, produce an aberrant basement membrane, and, sometimes, spread over the iris and nearby structures in a way that increases the risk for glaucoma.

Similarity: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Similarity: Contains 7 C2H2-type zinc fingers.

Similarity: Contains 1 homeobox DNA-binding domain.

Summary: TCF8 encodes a zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991 [PubMed 1840704]).[supplied by OMIM].

AREB6 reacts with human.

OMIM: 189909; gene. [NCBI / EBI]
609141; phenotype. [NCBI / EBI]

Products similar to AREB6 antibody:

IgG

zinc finger E-box binding homeobox 1 (ZEB1), IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for AREB6 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Williams. T.M. et al.. (1991) Science 254 (5039). 1791-1794.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: AREB6 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of AREB6 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about AREB6 antibody, all related information, articles, resources about AREB6 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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