TFDP1 antibody, TFDP1 (transcription factor Dp-1) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

TFDP1 (transcription factor Dp-1) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-43022

Buy TFDP1 antibody -

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Related Product Names:

- TFDP1 antibody; TFDP1; DP1, DRTF1, Dp-1; TFDP1 (transcription factor Dp-1)
- E2F dimerization partner 1; DRTF1-polypeptide 1; DRTF1; Transcription factor Dp-1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: TFDP1	Gene Name Synonym: DP1, DRTF1, Dp-1
Gi #: 6005900	NCBI Acc #: NP_009042.1	Swiss Prot Acc #: Q14186
Length (aa): 410	Mol. Weight (Da): 45070	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human TFDP1.

ELISA Titre: 1:312500

Category: Transcription Factor Antibodies

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 2.0 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for TFDP1 ANTIBODY:

IHC-P. WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

IHC: ( anti-TFDP1 )

TFDP1 antibody IHC image
TFDP1

WB: ( anti-TFDP1 )

TFDP1 antibody WB image
TFDP1

TFDP1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for TFDP1 antibody: TFDP1; DP1, DRTF1, Dp-1; E2F dimerization partner 1; DRTF1-polypeptide 1; DRTF1; Transcription factor Dp-1

The E2F transcription factor family regulates the expression of various cellular promoters. particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the

Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.

Subunit: Component of the E2F/DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC). During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the DRTF1/E2F complex to render E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0 phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of the DREAM complex composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBBP4, RBL2, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

Subcellular Location: Nucleus.

Tissue Specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.

Induction: Down-regulated during differentiation.

Ptm: Phosphorylation by E2F-1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.

Miscellaneous: E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP.

Similarity: Belongs to the E2F/DP family.

Summary: The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM].

TFDP1 (transcription factor Dp-1) reacts with human.

OMIM: 189902; gene. [NCBI / EBI]

Products similar to TFDP1 antibody:

IgG

DP1, IgG

DP1 [SPM178], IgG

DP1, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for TFDP1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Yasui.K.. et al.. (2003) J. Hum. Genet. 48 (12). 609-613.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: TFDP1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of TFDP1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TFDP1 antibody, all related information, articles, resources about TFDP1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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