EGR2 antibody, EGR2 (early growth response 2 (Krox-20 homolog. Drosophila)) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

EGR2 (early growth response 2 (Krox-20 homolog. Drosophila)) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-43032

Buy EGR2 antibody -

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Related Product Names:

- EGR2 antibody; EGR2; CMT1D, CMT4E, DKFZp686J1957, FLJ14547, KROX20; EGR2 (early growth response 2 (Krox-20 homolog. Drosophila))
- EGR-2; Protein Krox-20; AT591; Early growth response 2 protein; Early growth response protein 2

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: EGR2	Gene Name Synonym: CMT1D, CMT4E, DKFZp686J1957, FLJ14547, KROX20
Gi #: 9845524	NCBI Acc #: NP_000390.2	Swiss Prot Acc #: P11161
Length (aa): 476	Mol. Weight (Da): 50302	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human EGR2.

Description: The early growth response protein 2 (EGR2) is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1.The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Reconstitution and Storage: Avoid repeat freeze-thaw cycles.

ELISA Titre: 1:312500

Species Reactivity: Human, Mouse.

Quality Control: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. For research use only not for diagnostic, human, or veterinary use.

Category: Transcription Factor Antibodies

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for EGR2 ANTIBODY:

IHC-P. WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

IHC: ( anti-EGR2 )

EGR2 antibody IHC image
EGR2

WB: ( anti-EGR2 )

EGR2 antibody WB image
EGR2

EGR2 ANTIBODY TARGET DESCRIPTION:

Synonym Names for EGR2 antibody: EGR2; CMT1D, CMT4E, DKFZp686J1957, FLJ14547, KROX20; EGR-2; Protein Krox-20; AT591; Early growth response 2 protein; Early growth response protein 2

The early growth response protein 2 (EGR2) is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease. type 1.

Function: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.

Subunit: Interacts with HCFC1.

Subcellular Location: Nucleus.

Disease: Defects in EGR2 are a cause of congenital hypomyelination neuropathy (CHN) [MIM:605253]. Inheritance can be autosomal dominant or recessive. Recessive CHN is also known as Charcot-Marie-Tooth disease type 4E (CMT4E). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness, and very slow nerve conduction velocities.

Disease: Defects in EGR2 are a cause of Charcot-Marie-Tooth disease type 1D (CMT1D) [MIM:607678]. CMT1D is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.

Disease: Defects in EGR2 are a cause of Dejerine-Sottas syndrome (DSS) [MIM:145900]; also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.

Similarity: Belongs to the EGR C2H2-type zinc-finger protein family.

Similarity: Contains 3 C2H2-type zinc fingers.

Summary: The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1.

EGR2 (early growth response 2 (Krox-20 homolog. Drosophila)) reacts with human.

OMIM: 129010; gene. [NCBI / EBI]
145900; phenotype. [NCBI / EBI]
605253; phenotype. [NCBI / EBI]
607678; phenotype. [NCBI / EBI]

Products similar to EGR2 antibody:

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EGR2, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for EGR2 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Yoo.Y.G.. et al.. (2004) J. Biol. Chem. 279 (35). 36242-36249.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: EGR2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of EGR2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about EGR2 antibody, all related information, articles, resources about EGR2 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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