NFKBIA antibody, NFKBIA Antibody, Rabbit Polyclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

NFKBIA Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-43046

Buy NFKBIA antibody -

Size:

Related Product Names:

- NFKBIA antibody; NFKBIA; IKBA, MAD-3, NFKBI; NFKBIA
- I-kappa-B-alpha; IkappaBalpha; IkB-alpha; Major histocompatibility complex enhancer-binding protein MAD3; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; NF-kappa-B inhibitor alpha

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: NFKBIA	Gene Name Synonym: IKBA, MAD-3, NFKBI
Gi #: 10092619	NCBI Acc #: NP_065390.1	Swiss Prot Acc #: P25963
Length (aa): 317	Mol. Weight (Da): 35609	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human NFKBIA.

ELISA Titre: 1:1562500

Category: Transcription Factor Antibodies

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for NFKBIA ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-NFKBIA )

NFKBIA antibody WB image
NFKBIA

NFKBIA ANTIBODY TARGET DESCRIPTION:

Synonym Names for NFKBIA antibody: NFKBIA; IKBA, MAD-3, NFKBI; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; Major histocompatibility complex enhancer-binding protein MAD3; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; NF-kappa-B inhibitor alpha

NFKB1 or NFKB2 is bound to REL. RELA. or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB). which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-

Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa-B.

Subunit: Interacts with RELA. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X.

Subcellular Location: Cytoplasm.

Induction: Induced in adherent monocytes.

Ptm: Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity.

Ptm: Ubiquitinated; subsequent to stimulus-dependent phosphorylation on serines, polyubiquitination targets the protein for rapid degradation via the ubiquitin system.

Disease: Defects in NFKBIA are a cause of autosomal dominant anhidrotic ectodermal dysplasia with immunodeficiency (AD-EDA-ID) [MIM:164008]. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia.

Similarity: Belongs to the NF-kappa-B inhibitor family.

Similarity: Contains 5 ANK repeats.

Summary: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM].

NFKBIA reacts with human.

OMIM: 164008; gene+phenotype. [NCBI / EBI]

Products similar to NFKBIA antibody:

IgG

Rabbit anti IkB-alpha (C-terminal), IgG

IKB alpha cleaved, IgG

NF KAPPA B INHIBITOR ALPHA, IgG

IKB alpha, IgG

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, IgG

Peptide

IkappaB-alpha (Phospho-Tyr42) Antibody Blocking Peptide, Peptide

IkB-alpha (C-terminal) Control Peptide, Peptide

IkappaB-alpha (Phospho-Ser32/Ser36) Antibody Blocking Peptide, Peptide

PRODUCT INTERACTIONS:

NFKBIA interacts with Inhibitor of nuclear factor kappa-B kinase alpha subunit, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK alpha [14A231], IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK -alpha (Phospho-Thr23), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK -alpha (Ab-23), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK -alpha (Phospho-Thr23) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Rabbit A' IKK-alpha, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK-alpha Control Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-IKK alpha, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-IKK alpha CONTROL PEPTIDE, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK alpha phospho S176, S180, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Inhibitor of nuclear factor kappa B kinase subunit beta, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKKb, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK beta [10AG2], IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK beta [10A9B6], IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Rabbit A' IKK-beta, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with IKK-beta Control Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-IKK beta, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-IKK beta CONTROL PEPTIDE, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with RELA, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkB p65, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Phospho-Ser529), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Ab-529), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 ( (phospho-Ser311), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Ab-311), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Phospho-Thr254), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Phospho-Ser276), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Phospho-Thr435), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Phospho-Ser468), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Phospho-Ser536), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Ab-254), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Ab-276), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB -p65 (Ab-435), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Ab-468), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NF-kappaB-p65 (Ab-536), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkappaB-p65 (Phospho-Thr254) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkappaB-p65 (Phospho-Ser276) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkappaB-p65 (Phospho-Thr435) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkappaB-p65 (Phospho-Ser468) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkappaB-p65 (Phospho-Ser536) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkappaB-p65 (Phospho-Ser529) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkappaB-p65 (phospho-Ser311) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Rabbit anti p65 (RelA) N-terminal, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Rabbit anti p65 (RelA) C-terminal, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-NFKB p65 (Rel A) phospho specific pS276, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-NFKB p65 (Rel A) phospho specific pS529, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-NFKB p65 (Rel A), IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-NFKB p65 (Rel A) N-TERMINAL SPECIFIC, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-NFKB p65 (Rel A) phospho specific pS536, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with Anti-NFKB p65 NLS specific, IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkB p65 [NF-12], IgG (GenWay Catalog #: 18-003-43046).

NFKBIA interacts with NFkB p65, IgG (GenWay Catalog #: 18-003-43046).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for NFKBIA ANTIBODY:

Background references for antibody target are not specific to GenWay products

Janssen.R.. et al.. (2004) J. Exp. Med. 200 (5). 559-568.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: NFKBIA antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of NFKBIA antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about NFKBIA antibody, all related information, articles, resources about NFKBIA antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved