Alphabetical Listing of Primary Antibodies:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
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H
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I
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J
|
K
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L
|
M
|
N
|
O
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P
|
Q
|
R
|
S
|
T
|
U
|
V
|
W
|
X
|
Y
|
Z
|
Alphabetical Listing of Proteins:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
|
P
|
Q
|
R
|
S
|
T
|
U
|
V
|
W
|
X
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Y
|
Z
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Peptides
|
Secondary Antibodies
|
ELISA Kits
TBP (TATA box binding protein) Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-003-43056
Buy TBP antibody -
Size:
0.1 mg ($255.00)
Related Product Names:
- TBP antibody; TBP; GTF2D, GTF2D1, SCA17, TFIID; TBP (TATA box binding protein)
- TATA-box factor; TATA-binding factor; TATA sequence-binding protein; Transcription initiation factor TFIID TBP subunit; TATA box binding protein; TATA-box-binding protein
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
TBP
Gene Name Synonym:
GTF2D, GTF2D1, SCA17, TFIID
Gi #:
4507379
NCBI Acc #:
NP_003185.1
Swiss Prot Acc #:
P20226
Length (aa):
339
Mol. Weight (Da):
37698
Chrom Location:
N/A
Antigen Specificity:
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human TBP with an internal ID of P02082.
Western Blot:
Suggested dilution at 2.5µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody.
ELISA Titre:
1:62500
Category:
Beta-Scaffold Factors with Minor Grove Contacts
Note:
Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host:
Rabbit
Purity/Purification:
Rabbit IgG purified by protein A chromatography.
Clonality:
Polyclonal
Crossreactivity:
Human
Format:
Suggested dilution at 2.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage:
Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 ul of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C. Avoid repeat freeze-thaw cycles.
Stability:
Note: Avoid repeat freeze-thaw cycles.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for TBP ANTIBODY:
WB: Tested
TESTING: (
secondary reagents
and
protocols
[IHC Protocol]
)
WB:
( anti-TBP )
TBP antibody WB image
TBP ANTIBODY TARGET DESCRIPTION:
Synonym Names for TBP antibody:
TBP; GTF2D, GTF2D1, SCA17, TFIID; TATA-box factor; TATA-binding factor; TATA sequence-binding protein; Transcription initiation factor TFIID TBP subunit; TATA box binding protein; TATA-box-binding protein
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID). which binds to the core promoter to position the polymerase properly.
Function:
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subunit:
Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Component of the transcription factor SL1/TIFIB complex, composed of TBP and at least TAF1A, TAF1B TAF1C, and TAF3. Binds DNA as monomer. Interacts with TAFs, TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with HIV-1 Tat. Interacts with UTF1 which acts as a coactivator of ATF2 transcriptional activity. Interacts with GPBP1 (By similarity).
Subcellular Location:
Nucleus.
Polymorphism:
The poly-Gln region of TBP is highly polymorphic (25 to 42 repeats) in normal individuals and is expanded to about 47-63 repeats in spinocerebellar ataxia 17 (SCA17) patients.
Disease:
Defects in TBP are the cause of spinocerebellar ataxia 17 (SCA17) [MIM:607136]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
Similarity:
Belongs to the TBP family.
Summary:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This protein is TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
TBP (TATA box binding protein) reacts with human.
OMIM:
600075; gene. [
NCBI
/
EBI
]
607136; phenotype. [
NCBI
/
EBI
]
Products similar to TBP antibody:
IgG
CtBP1, IgG
CtIP [19E8], IgG
TBP Associated Factor 1 [0.T.145], IgG
TNF receptor I, IgG
TATA box binding protein, IgG
PRODUCT INTERACTIONS:
TBP (TATA box binding protein)
interacts
with
EDF1 (endothelial differentiation-related factor 1), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
Transcription initiation factor IIA gamma chain, Protein
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
MDM2 [2A10], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
MDM2 [SMP14], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
MDM2 [SMP14], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
Rabbit anti Mouse MDM2 pS185, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
MDM2 [HDM2-323], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
MDM2 [MD-219], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
MDM2 (ready-to-use), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
POU3F2 (POU domain. class 3. transcription factor 2), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
POU3F2, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
TBP Associated Factor 1 [0.T.145], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
TAF1 (TAF1 RNA polymerase II. TATA box binding protein (TBP)-associated factor. 250kDa), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
Anti-Transcription Initiation Factor TFIID Subunit 1 (TAF1), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
Cellular tumor antigen p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
Cellular tumor antigen p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 Human, Protein
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53M Human, Protein
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [SP5], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 phospho S15, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [DO-13], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [DO-7], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [Pab240], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [D01], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [3F301], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [DO-7] (ready-to-use), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [BP53-12], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
I-kappaB-alpha (Phospho-Ser32/Ser36), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Phospho-Ser15), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Phospho-Ser46), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Phospho-Ser315), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Ab-15), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Ab-46), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Ab-315), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Phospho-Ser15) Antibody Blocking Peptide, Peptide
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Phospho-Ser46) Antibody Blocking Peptide, Peptide
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (Phospho-Ser315) Antibody Blocking Peptide, Peptide
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
TP53 (tumor protein p53 (Li-Fraumeni syndrome)), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (a.a. 32-79), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (a.a. 88-109), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 (a.a. 306-393), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
Mouse p53, Wild Type, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
Human p53 Oncogene, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [B20.1 (BP 53.122)] antibody (ready-to-use), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 AIP1, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [BP53-12] (FITC), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [DO-2], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [DO-1], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
P53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [B20.1 (BP 53.122)] antibody (FITC), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
P53 [SP5] (ready-to-use), IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [DO-1], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [B449], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [Pab240], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [Pab1801], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [Pab1801], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [D01], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53 [DO-2], IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
TBP (TATA box binding protein)
interacts
with
p53, IgG
(GenWay Catalog #: 18-003-43056)
.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for TBP ANTIBODY:
Background references for antibody target are not specific to GenWay products
Reid.S.J.. et al.. (2004) Brain Res. Mol. Brain Res. 125 (1-2). 120-128.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
TBP antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of TBP antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TBP antibody, all related information, articles, resources about TBP antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.
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Myeloid leukemia factor 1
NANOG (Nanog homeobox)
NAP-2 Human
NFKB2 (nuclear factor of kappa light pol...
NFKB2 (nuclear factor of kappa light pol...
NOTCH3 (Notch homolog 3 (Drosophila))
OPG Human, His
OSM Human
P-Sel Human
p21 Human
P27 kip1 protein
P40
p53 Human
Parathyroid Hormone
PAX5 (paired box gene 5 (B-cell lineage ...
PCNA (proliferating cell nuclear antigen...
PCNA Human
PDGF-BB Human, Yeast
PDGF-BB Mouse
Peripheral-type benzodiazepine receptor
PfHSP70
PKC-a Human
PKC-d Human
PREB (prolactin regulatory element bindi...
PRL-R Bovine
PRL-R Ovine
Pro-epidermal growth factor
Prolactin
Prolactin Human
Prolactin Ovine
Prostate-specific antigen
Protein p65
PTEN Human
PTH 1-34 Human
PTH Human 1-84
Putative transmembrane receptor
Putative transmembrane receptor
Putative transmembrane receptor
RAC-alpha serine/threonine-protein kinas...
Rantes Human
RAP Rat
Ras-related C3 botulinum toxin substrate...
RB1 (retinoblastoma 1 (including osteosa...
RELA
Rhodopsin
RTSbeta
RUNX1T1 (runt-related transcription fact...
RUNX2 (runt-related transcription factor...
SARS Core 1-49
SARS Core 1-49, 192-220
SARS Core 340-390
SCF (Stem Cell Factor)
SCF Human
SCF Human, Sf9
SCF Mouse
SCF Rat
SDF-1a Human
SDF-1a Mouse
SDF-1b Human
SDF-1b Mouse
Serum amyloid P-component
Signal transducer and activator of trans...
SMAD3 (SMAD family member 3)
SPA
STAT1 Human
STAT3 Human
T-cell-specific surface glycoprotein CD2...
T.gondii p30
TAL1
TAL1 (T-cell acute lymphocytic leukemia ...
TATA-binding protein-associated phosphop...
TBP (TATA box binding protein)
TNFRI Human
TNFRSF10A (tumor necrosis factor recepto...
TOP1 Human
TP53 (tumor protein p53 (Li-Fraumeni syn...
tPA Human
TPO Human
TPO Human
TPO Mouse
TRIM5 alpha
TRIM5 alpha
TRIM5 alpha
Tripartite motif-containing 5 alpha isof...
Tripartite motif-containing 5 alpha isof...
TRX Yeast
Trypsin Bovine
Tumor necrosis factor receptor superfami...
Tumor necrosis factor receptor superfami...
Tyrosine-protein kinase BTK
Ubiquitin Human
VEGF (121) Human, Sf9
Vim Human
ZNFN1A1
Products Type:
IgG
IgY
Protein
Peptide
Applications:
ELISA
FACS
ICC
IF
IHC
IP
RIA
WB
Source:
Amphibian
Bovine
Canine
Chicken
Equine
Feline
Goat
Hamster
Mouse
Porcine
Primate
Rabbit
Rat
Sheep
Xenopus
Zebrafish
Xreactivity:
Amphibian
Bovine
Canine
Chicken
Drosophila
Equine
Feline
Goat
Hamster
Human
Insect
Mouse
Porcine
Primate
Rabbit
Rat
Sheep
Viral
Xenopus
Zebrafish
Conjugate:
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BGAL
Biotin
Cy5
FITC
HRP
Microbeads
RPE
Texas Red
TRITC
Specific Categories
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Proteins
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