|
|
| OLIG2 (oligodendrocyte lineage transcription factor 2) Antibody, Rabbit Polyclonal Antibody |
 |
|
|
 |
| Catalog Number: 18-003-43089 |
|
|
|
| Related Product Names:
|
-
OLIG2 antibody; OLIG2; BHLHB1, OLIGO2, PRKCBP2, RACK17; OLIG2 (oligodendrocyte lineage transcription factor 2)
- Oligo2; Class B basic helix-loop-helix protein 1; bHLHB1; Protein kinase C-binding protein RACK17; Protein kinase C-binding protein 2; Oligodendrocyte lineage transcription factor 2; Oligodendrocyte transcription factor 2 |
|
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
|
|
| Gene Name: OLIG2 |
Gene Name Synonym: BHLHB1, OLIGO2, PRKCBP2, RACK17 |
Gi #:
17978475 |
NCBI Acc #:
NP_005797.1 |
Swiss Prot Acc #:
Q13516 |
Length (aa): 323 |
Mol. Weight (Da): 32385 |
Chrom Location: N/A |
|
|
 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human OLIG2.
ELISA Titre: 1:312500
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.
Clonality: Polyclonal
Crossreactivity: Human
Format: Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
|
| APPLICATIONS for OLIG2 ANTIBODY: |
| WB: Tested |
|
|
|
|
| OLIG2 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for OLIG2 antibody: OLIG2; BHLHB1, OLIGO2, PRKCBP2, RACK17; Oligo2; Class B basic helix-loop-helix protein 1; bHLHB1; Protein kinase C-binding protein RACK17; Protein kinase C-binding protein 2; Oligodendrocyte lineage transcription factor 2; Oligodendrocyte transcription factor 2
OLIG2 is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. OLIG2 is an essential regulator of ventral neuroectodermal progenitor cell fate. It is associated with T-cell acute lymphoblastic leukemia d
Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).
Subunit: Interacts with NKX2-2 (By similarity).
Subcellular Location: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity).
Tissue Specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
Induction: By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).
Domain: The bHLH is essential for interaction with NKX2-2 (By similarity).
Disease: A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain.
Summary: This protein is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
OLIG2 (oligodendrocyte lineage transcription factor 2) reacts with human.
OMIM: 606386; gene. [NCBI / EBI]
|
|
|
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
|
|
| BACKGROUND
REFERENCES for OLIG2 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Sun.T.. et al.. (2006) Dev. Biol. 292 (1). 152-164. |
|
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: OLIG2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of OLIG2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about OLIG2 antibody, all related information, articles, resources about OLIG2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
|
|
|
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
|
|
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
|
|
