SMAD1 antibody, SMAD1 (SMAD family member 1) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

SMAD1 (SMAD family member 1) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-43237

Buy SMAD1 antibody -

Size:

Trial Size Available. Please expect delivery of trial size products to be 4 weeks.

Related Product Names:

- SMAD1 antibody; SMAD1; BSP1, JV4-1, JV41, MADH1, MADR1; SMAD1 (SMAD family member 1)
- SMAD 1; Mothers against DPP homolog 1; Mad-related protein 1; Transforming growth factor-beta-signaling protein 1; BSP-1; hSMAD1; JV4-1; Sma- and Mad-related protein 1; Mothers against decapentaplegic homolog 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: SMAD1	Gene Name Synonym: BSP1, JV4-1, JV41, MADH1, MADR1
Gi #: 5174509	NCBI Acc #: NP_005891.1	Swiss Prot Acc #: Q15797
Length (aa): 465	Mol. Weight (Da): 52260	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human SMAD1.

ELISA Titre: 1:1562500

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit IgG purified by protein A chromatography.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 0.625 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for SMAD1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-SMAD1 )

SMAD1 antibody WB image
SMAD1

SMAD1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for SMAD1 antibody: SMAD1; BSP1, JV4-1, JV41, MADH1, MADR1; SMAD 1; Mothers against DPP homolog 1; Mad-related protein 1; Transforming growth factor-beta-signaling protein 1; BSP-1; hSMAD1; JV4-1; Sma- and Mad-related protein 1; Mothers against decapentaplegic homolog 1

SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs). which are involved in a range of biologic

Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).

Subunit: Interacts with HGS and NANOG (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes.

Subcellular Location: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.

Tissue Specificity: Ubiquitous. Highest expression seen in the heart and skeletal muscle.

Ptm: Phosphorylated on serine by BMP type 1 receptor kinase.

Ptm: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.

Similarity: Belongs to the dwarfin/SMAD family.

Similarity: Contains 1 MH1 (MAD homology 1) domain.

Similarity: Contains 1 MH2 (MAD homology 2) domain.

Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

SMAD1 (SMAD family member 1) reacts with human.

OMIM: 601595; gene. [NCBI / EBI]

Products similar to SMAD1 antibody:

IgG

SMAD1 (SMAD family member 1), IgG

SMAD family member 1 (SMAD1), transcript variant 1, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for SMAD1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Jadlowiec.J.A.. et al.. (2006) J. Biol. Chem. 281 (9). 5341-5347.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: SMAD1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of SMAD1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SMAD1 antibody, all related information, articles, resources about SMAD1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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