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| SNAI2 (snail homolog 2 (Drosophila)) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-003-43430 |
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| Related Product Names:
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SNAI2 antibody; SNAI2; MGC10182, SLUG, SLUGH1, WS2D; SNAI2 (snail homolog 2 (Drosophila))
- Neural crest transcription factor Slug; Snail homolog 2; Snail 2; Zinc finger protein SLUG |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: SNAI2 |
Gene Name Synonym: MGC10182, SLUG, SLUGH1, WS2D |
Gi #:
11276067 |
NCBI Acc #:
NP_003059.1 |
Swiss Prot Acc #:
O43623 |
Length (aa): 268 |
Mol. Weight (Da): 29986 |
Chrom Location: N/A |
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 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human SNAI2.
ELISA Titre: 1:62500
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.
Clonality: Polyclonal
Crossreactivity: Human, Dog
Format: Suggested dilution at 0.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for SNAI2 ANTIBODY: |
| IHC-P. WB: Tested |
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| SNAI2 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for SNAI2 antibody: SNAI2; MGC10182, SLUG, SLUGH1, WS2D; Neural crest transcription factor Slug; Snail homolog 2; Snail 2; Zinc finger protein SLUG
SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is in
Function: Transcriptional repressor. Involved in the generation and migration of neural crest cells.
Subcellular Location: Nucleus (Probable).
Tissue Specificity: Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.
Disease: Defects in SNAI2 are a cause of neural tube defects (NTD).
Disease: Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. Waardenburg syndrome (WS; deafness with pigmentary abnormalities) is a congenital disorder caused by defective function of the embryonic neural crest. Depending on additional symptoms, WS is classified into four types: WS1, WS2, WS3 and WS4. WS2 is a heterogeneous, predominantly sporadic disorder with auditory and pigmentary features identical to those of WS1 [MIM:193500] but without dystopia canthorum.
Similarity: Belongs to the snail C2H2-type zinc-finger protein family.
Similarity: Contains 5 C2H2-type zinc fingers.
Summary: This protein is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.
SNAI2 (snail homolog 2 (Drosophila)) reacts with human, dog.
OMIM: 602150; gene. [NCBI / EBI]
608890; phenotype. [NCBI / EBI]
Products similar to SNAI2 antibody:
IgG
 SLUG, IgG
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for SNAI2 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Moody.S.E.. (2005) Cancer Cell 8 (3). 197-209. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: SNAI2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of SNAI2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SNAI2 antibody, all related information, articles, resources about SNAI2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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