Alphabetical Listing of Primary Antibodies:
f
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0-4
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5-9
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A
|
B
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C
|
D
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E
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F
|
G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
|
Z
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Alphabetical Listing of Proteins:
f
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0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
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P
|
Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
|
ELISA Kits
ACO1 (aconitase 1. soluble) Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-003-43581
Buy ACO1 antibody -
Size:
0.05 mg ($320.00)
Related Product Names:
- ACO1 antibody; ACO1; IREB1, IREBP, IRP1; ACO1 (aconitase 1. soluble)
- IRE-BP 1; Iron regulatory protein 1; IRP1; Ferritin repressor protein; Aconitate hydratase; EC 4.2.1.3; Citrate hydro-lyase; Aconitase; Aconitase 1; Iron-responsive element-binding protein 1
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
ACO1
Gene Name Synonym:
IREB1, IREBP, IRP1
Gi #:
8659555
NCBI Acc #:
NP_002188.1
Swiss Prot Acc #:
P28271
Length (aa):
889
Mol. Weight (Da):
98179
Chrom Location:
N/A
Antigen Specificity:
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human ACO1.
Western Blot:
Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
ELISA Titre:
1:62500
Category:
RNA Binding Proteins
Note:
Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host:
Rabbit
Purity/Purification:
Rabbit Ig G is purified by peptide affinity chromatography method.
Clonality:
Polyclonal
Crossreactivity:
Human, Rat
Storage:
Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability:
Note: Avoid repeat freeze-thaw cycles.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for ACO1 ANTIBODY:
IHC-P. WB: Tested
TESTING: (
secondary reagents
and
protocols
[IHC Protocol]
)
IHC:
( anti-ACO1 )
ACO1 antibody IHC image
WB:
( anti-ACO1 )
ACO1 antibody WB image
ACO1 ANTIBODY TARGET DESCRIPTION:
Synonym Names for ACO1 antibody:
ACO1; IREB1, IREBP, IRP1; IRE-BP 1; Iron regulatory protein 1; IRP1; Ferritin repressor protein; Aconitate hydratase; EC 4.2.1.3; Citrate hydro-lyase; Aconitase; Aconitase 1; Iron-responsive element-binding protein 1
ACO1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Function:
Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Function:
This protein also expresses aconitase activity.
Catalytic Activity:
Citrate = isocitrate.
Cofactor:
Binds 1 4Fe-4S cluster per subunit (By similarity).
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the aconitase/IPM isomerase family.
Summary:
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
ACO1 (aconitase 1. soluble) reacts with human, rat.
OMIM:
NCBI [
100880
]
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for ACO1 ANTIBODY:
Background references for antibody target are not specific to GenWay products
Clarke.S.L.. (2006) EMBO J. 25 (3). 544-553.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
ACO1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of ACO1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ACO1 antibody, all related information, articles, resources about ACO1 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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