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| PABPC4 (poly (A) binding protein. cytoplasmic 4 (inducible form)) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-003-43591 |
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| Related Product Names:
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PABPC4 antibody; PABPC4; APP-1, APP1, PABP4, iPABP; PABPC4 (poly (A) binding protein. cytoplasmic 4 (inducible form))
- Poly(A)-binding protein 4; PABP 4; Inducible poly(A)-binding protein; iPABP; Activated-platelet protein 1; APP-1; Poly A binding protein, cytoplasmic 4; Polyadenylate-binding protein 4 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: PABPC4 |
Gene Name Synonym: APP-1, APP1, PABP4, iPABP |
Gi #:
4504715 |
NCBI Acc #:
NP_003810.1 |
Swiss Prot Acc #:
Q13310 |
Length (aa): 644 |
Mol. Weight (Da): 70783 |
Chrom Location: N/A |
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 Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human PABPC4.
Western Blot: Suggested dilution at 1.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
ELISA Titre: 1:312500
Category: RNA Binding Proteins
Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host: Rabbit
Purity/Purification: Rabbit IgG purified by protein A chromatography.
Clonality: Polyclonal
Crossreactivity: Human, Dog
Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability: Note: Avoid repeat freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for PABPC4 ANTIBODY: |
| IHC-P. WB: Tested |
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| PABPC4 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for PABPC4 antibody: PABPC4; APP-1, APP1, PABP4, iPABP; Poly(A)-binding protein 4; PABP 4; Inducible poly(A)-binding protein; iPABP; Activated-platelet protein 1; APP-1; Poly A binding protein, cytoplasmic 4; Polyadenylate-binding protein 4
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 m
Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
Subcellular Location: Cytoplasm.
Tissue Specificity: Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.
Ptm: Arg-518 is dimethylated, probably to asymmetric dimethylarginine.
Similarity: Belongs to the polyadenylate-binding protein type-1 family.
Similarity: Contains 1 PABC domain.
Similarity: Contains 4 RRM (RNA recognition motif) domains.
Summary: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.
PABPC4 (poly (A) binding protein. cytoplasmic 4 (inducible form)) reacts with human, dog.
OMIM: 603407; gene. [NCBI / EBI]
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| PRODUCT INTERACTIONS: |
PABPC4 (poly (A) binding protein. cytoplasmic 4 (inducible form)) interacts with ARF6 [SPM371], IgG (GenWay Catalog #: 18-003-43591).
PABPC4 (poly (A) binding protein. cytoplasmic 4 (inducible form)) interacts with 14-3-3 protein zeta/delta, Protein (GenWay Catalog #: 18-003-43591).
PABPC4 (poly (A) binding protein. cytoplasmic 4 (inducible form)) interacts with 14-3-3 zeta (Phospho-Ser58), IgG (GenWay Catalog #: 18-003-43591).
PABPC4 (poly (A) binding protein. cytoplasmic 4 (inducible form)) interacts with 14-3-3 zeta (Ab-58), IgG (GenWay Catalog #: 18-003-43591).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for PABPC4 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| Lehner.B. (2004) Genome Res. 14 (7). 1315-1323. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: PABPC4 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of PABPC4 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about PABPC4 antibody, all related information, articles, resources about PABPC4 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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