KIN antibody, KIN (KIN. antigenic determinant of recA protein homolog (mouse)) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

KIN (KIN. antigenic determinant of recA protein homolog (mouse)) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-43816

Buy KIN antibody -

Size:

Trial Size Available. Please expect delivery of trial size products to be 4 weeks.

Related Product Names:

- KIN antibody; KIN; BTCD; KIN17; KIN (KIN. antigenic determinant of recA protein homolog (mouse))
- Protein KIN homolog; Binding to curved DNA; HsKin17 protein; KIN, antigenic determinant of recA protein homolog

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: KIN	Gene Name Synonym: BTCD; KIN17
Gi #: 13124883	NCBI Acc #: NP_036443.1	Swiss Prot Acc #: O60870
Length (aa): 393	Mol. Weight (Da): 45374	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human KIN.

ELISA Titre: 1:312500

Category: Transcription Factor Antibodies

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit IgG purified by protein A chromatography.

Clonality: Polyclonal

Crossreactivity: Human, Rat, Dog

Format: Suggested dilution at 2.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 ul of distilled water. Final antibody concentration is 2 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for KIN ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-KIN )

KIN antibody WB image
KIN

KIN ANTIBODY TARGET DESCRIPTION:

Synonym Names for KIN antibody: KIN; BTCD; KIN17; Protein KIN homolog; Binding to curved DNA; HsKin17 protein; KIN, antigenic determinant of recA protein homolog

Kin is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein. suggesting its participation in the cellular

Function: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.

Subunit: Interacts with SV40 large T antigen. Associated with DNA polymerase alpha, RFC1 and cyclin A, in multiprotein DNA replication complexes. Also associates with replication origins at the G1/S phase boundary and throughout the S phase in vivo.

Subcellular Location: Nucleus. Cytoplasm. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids.

Tissue Specificity: Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level).

Induction: By UVC irradiation in quiescent primary fibroblasts. By mitomycin C in human melanoma MeWO cells.

Domain: The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other positively charged residues, may possibly be the site of RNA-binding.

Miscellaneous: Recognized by antibodies directed against the RecA protein (By similarity).

Similarity: Contains 1 C2H2-type zinc finger.

Summary: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.

KIN (KIN. antigenic determinant of recA protein homolog (mouse)) reacts with human, rat, dog.

OMIM: 601720; gene. [NCBI / EBI]

Products similar to KIN antibody:

IgG

IP10, IgG

CX3CL1, IgG

IL2 [JES6-5H4] (Biotin), IgG

IL1 alpha [AS5], IgG

Syk [SYK-01], IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for KIN ANTIBODY:

Background references for antibody target are not specific to GenWay products

le Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62 (PT.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: KIN antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of KIN antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about KIN antibody, all related information, articles, resources about KIN antibody are being stored on our online database. Let us know if you have questions regarding this product.

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