Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
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0-4
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5-9
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A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
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P
|
Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
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ELISA Kits
MKL1 Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-003-44016
Buy MKL1 antibody -
Size:
0.1 mg ($255.00)
Related Product Names:
- MKL1 antibody; MKL1; AI852829, AMKL, AW743281, AW821984, Bsac, Mal, Mrtf-A; MKL1
- Myocardin-related transcription factor A; MRTF-A; Megakaryoblastic leukemia 1 protein homolog; Basic SAP coiled-coil transcription activator; Megakaryoblastic leukemia (translocation) 1 isoform 1 [Mus musculus]; MKL/myocardin-like protein 1
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
MKL1
Gene Name Synonym:
AI852829, AMKL, AW743281, AW821984, Bsac, Mal, Mrtf-A
Gi #:
127138894
NCBI Acc #:
NP_694629.2
Swiss Prot Acc #:
Q8K4J6
Length (aa):
964
Mol. Weight (Da):
102546
Chrom Location:
N/A
Antigen Specificity:
Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Mouse Mkl1.
Western Blot:
Suggested dilution at 1.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
ELISA Titre:
1:1562500
Category:
TF for Mouse
Note:
Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.
Source/Host:
Rabbit
Purity/Purification:
Rabbit IgG purified by protein A chromatography.
Clonality:
Polyclonal
Crossreactivity:
Mouse, Rat
Storage:
Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Stability:
Note: Avoid repeat freeze-thaw cycles.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for MKL1 ANTIBODY:
WB: Tested
TESTING: (
secondary reagents
and
protocols
[IHC Protocol]
)
WB:
( anti-MKL1 )
MKL1 antibody WB image
MKL1 ANTIBODY TARGET DESCRIPTION:
Synonym Names for MKL1 antibody:
MKL1; AI852829, AMKL, AW743281, AW821984, Bsac, Mal, Mrtf-A; Myocardin-related transcription factor A; MRTF-A; Megakaryoblastic leukemia 1 protein homolog; Basic SAP coiled-coil transcription activator; Megakaryoblastic leukemia (translocation) 1 isoform 1 [Mus musculus]; MKL/myocardin-like protein 1
MKL1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells.
Function:
Transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.
Subunit:
Forms a ternary complex with SRF on DNA. Interacts with MKL2. Some authors (Ref.1) have found contradictory results, they could not demonstrated that it forms a complex with the CArG boxes, even in the presence of SRF.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in heart, brain, spleen, lung, liver, muscle, kidney and testis.
Developmental Stage:
Detected throughout the embryo at 10.5 dpc; higher expression is found at 13.5 dpc in neural mesenchymal cells, skeletal muscle of the tongue, and epithelial cells of the colon and small intestine; at 15.5 dpc, expression in epithelial cells of lung, kidney, bladder, and colon is also detected.
Domain:
The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity.
Similarity:
Contains 3 RPEL repeats.
Similarity:
Contains 1 SAP domain.
MKL1 reacts with mouse, rat.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for MKL1 ANTIBODY:
Background references for antibody target are not specific to GenWay products
Sasazuki.T.. et al.. (2002) J. Biol. Chem. 277 (32). 28853-28860.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
MKL1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of MKL1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about MKL1 antibody, all related information, articles, resources about MKL1 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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