SYNCRIP antibody, SYNCRIP (synaptotagmin binding. cytoplasmic RNA interacting protein) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

SYNCRIP (synaptotagmin binding. cytoplasmic RNA interacting protein) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-44203

Buy SYNCRIP antibody -

Size:

Related Product Names:

- SYNCRIP antibody; SYNCRIP; GRY-RBP, HNRPQ1, NSAP1, RP1-3J17.2, dJ3J17.2, pp68; SYNCRIP (synaptotagmin binding. cytoplasmic RNA interacting protein)
- hnRNP Q; hnRNP-Q; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin binding, cytoplasmic RNA interacting protein; Heterogeneous nuclear ribonucleoprotein Q

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: SYNCRIP	Gene Name Synonym: GRY-RBP, HNRPQ1, NSAP1, RP1-3J17.2, dJ3J17.2, pp68
Gi #: 23397427	NCBI Acc #: NP_006363.3	Swiss Prot Acc #: O60506
Length (aa): 623	Mol. Weight (Da): 69603	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human SYNCRIP.

ELISA Titre: 1:312500

Western Blot: Suggested dilution at 1.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Category: RNA Binding Proteins

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit IgG purified by protein A chromatography.

Clonality: Polyclonal

Crossreactivity: Human, Mouse, Rat, Dog

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for SYNCRIP ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-SYNCRIP )

SYNCRIP antibody WB image
SYNCRIP

SYNCRIP ANTIBODY TARGET DESCRIPTION:

Synonym Names for SYNCRIP antibody: SYNCRIP; GRY-RBP, HNRPQ1, NSAP1, RP1-3J17.2, dJ3J17.2, pp68; hnRNP Q; hnRNP-Q; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin binding, cytoplasmic RNA interacting protein; Heterogeneous nuclear ribonucleoprotein Q

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. SYNCRIP may be involved in translationally coupled mRNA turnover. It implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. It interacts in vitro preferentially with poly(A) and poly(U) RNA sequences.

Function: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.

Subunit: Isoform 1 is a component of the APOB mRNA editosome complex and interacts with APOBEC1 and A1CF (APOBEC1 complementation factor). Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR, HNRPD and SYNCRIP. Isoform 3 interacts with HNRPR. Interacts with POLR2A hyperphosphorylated C-terminal domain. Interacts with minute virus of mice (MVM) NS1 protein. Isoform 1, isoform 2 and isoform 3 interact with SMN. Isoform 3 interacts through its C-terminal domain with SYT7, SYT8 and SYT9 (By similarity). The non-phosphorylated and phosphorylated forms are colocalized with PAIP1 in polysomes (By similarity). Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.

Subcellular Location: Cytoplasm (By similarity). Microsome (By similarity). Nucleus (By similarity). Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity).

Subcellular Location: Isoform 1: Nucleus, nucleoplasm (By similarity). Note=Expressed predominantly in the nucleoplasm (By similarity).

Subcellular Location: Isoform 2: Nucleus, nucleoplasm (By similarity). Note=Expressed predominantly in the nucleoplasm (By similarity).

Subcellular Location: Isoform 3: Nucleus, nucleoplasm (By similarity). Note=Expressed predominantly in the nucleoplasm (By similarity).

Tissue Specificity: Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.

Domain: The domain containing eight Arg-Gly-Gly repeats may be involved in RNA-binding and protein-protein interactions.

Ptm: Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA whereas the cytoplasmic form is poorly phosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity: Contains 3 RRM (RNA recognition motif) domains.

SYNCRIP (synaptotagmin binding. cytoplasmic RNA interacting protein) reacts with human, mouse, rat, dog.

Products similar to SYNCRIP antibody:

IgG

Heterogeneous nuclear ribonucleoprotein Q, IgG

SYNCRIP (synaptotagmin binding. cytoplasmic RNA interacting protein), IgG

PRODUCT INTERACTIONS:

SYNCRIP (synaptotagmin binding. cytoplasmic RNA interacting protein) interacts with PRKRA (protein kinase. interferon-inducible double stranded RNA dependent activator), IgG (GenWay Catalog #: 18-003-44203).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for SYNCRIP ANTIBODY:

Background references for antibody target are not specific to GenWay products

Bannai.H.. (2004) J. Biol. Chem. 279 (51). 53427-53434.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: SYNCRIP antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of SYNCRIP antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SYNCRIP antibody, all related information, articles, resources about SYNCRIP antibody are being stored on our online database. Let us know if you have questions regarding this product.

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