IGF2BP1 antibody, IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-44208

Buy IGF2BP1 antibody -

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Related Product Names:

- IGF2BP1 antibody; IGF2BP1; CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1; IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1)
- IGF2 mRNA-binding protein 1; IGF-II mRNA-binding protein 1; IMP-1; Coding region determinant-binding protein; CRD-BP; VICKZ family member 1; Zipcode-binding protein 1; Insulin-like growth factor 2 mRNA binding protein 1; Insulin-like growth factor 2 mRNA-binding protein 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: IGF2BP1	Gene Name Synonym: CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1
Gi #: 56237027	NCBI Acc #: NP_006537.3	Swiss Prot Acc #: Q9NZI8
Length (aa): 577	Mol. Weight (Da): 63456	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human IGF2BP1.

Western Blot: Suggested dilution at 0.25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

ELISA Titre: 1:312500

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Crossreactivity: Human, Rat

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for IGF2BP1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-IGF2BP1 )

IGF2BP1 antibody WB image
IGF2BP1

IGF2BP1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for IGF2BP1 antibody: IGF2BP1; CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1; IGF2 mRNA-binding protein 1; IGF-II mRNA-binding protein 1; IMP-1; Coding region determinant-binding protein; CRD-BP; VICKZ family member 1; Zipcode-binding protein 1; Insulin-like growth factor 2 mRNA binding protein 1; Insulin-like growth factor 2 mRNA-binding protein 1

IGF2BP1 is a member of the IGF-II mRNA-binding protein (IMP) family. The protein contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Function: RNA-binding factor that affects mRNA nuclear export, localization, stability and translation. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulates its subcellular localization and translation. Binds both to the coding region mRNA stability determinant (CRD) and to AU-rich sequences in the 3'-UTR of the MYC and CD44 mRNAs and stabilizes these mRNAs. Binds to the fourth and fifth exons of the oncofetal H19 and neuron-specific TAU mRNAs and regulates their localizations. Binds to the adenine-rich autoregulatory sequence (ARS) 5'-UTR of the PABPC1 mRNA and is involved in its translational repression. The RNA-binding activity to ARS is stimulated by PABPC1. Binds to the coding sequence region of BTRC/FBW1A mRNA and mediates stabilization of BTRC/FBW1A and MYC mRNAs in response to beta-catenin signaling. Binding to RNA employs a cooperative, sequential mechanism of homo- or heterodimerisation. Also involved in growth or survival of lung-cancer cells. Protects the MYC and MDR-1 mRNAs from cleavage by a endoribonuclease, thus prolonging their stabilities (By similarity). Binds to the 3'-UTR axonal localization signal (ALS) of TAU mRNA (By similarity). Binds to a conserved 54-nucleotide element in the 3'-UTR of the beta actin mRNA known as the 'zipcode' (By similarity). Promotes translocation of the beta-actin mRNA to dendrites (By similarity). May act as a regulator of mRNA transport to activated synapses in response to synaptic activity (By similarity).

Subunit: Can form homo- and heterodimers with IGF2BP1 or IGF2BP3. Associates with mRNP complex. Found in a RNP granule complex with FMR1. Interacts with FMR1. Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts through the third and fourth KH domains with PABPC1 in a RNA-independent manner. Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity). Interacts with ELAVL4 in a RNA-dependent manner (By similarity). Associates with microtubules and polysomes (By similarity).

Subcellular Location: Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Colocalized with H19 RNA at lamellipodia. Colocalized with CD44 mRNA in RNP granules. Nuclear export is mediated by XPO1/CRM1. In motile cells, is transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity). Present in the form of granules and into F-actin-rich protrusion of dendrites, spines and subsynaptic sites (By similarity). Colocalizes with beta-actin mRNA in dendrites and spines (By similarity). Exhibited rapid, bidirectional movements in dendrites and spines (By similarity). Neuronal depolarization by KCl induces its rapid efflux from the cell body into dendrites (By similarity).

Tissue Specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary, gonocytes of testis, oocytes, spermatogonia and semen (at protein level). Expressed in testicular and lung cancer (at protein level). Expressed in kidney, prostate, trachea, testis and lung cancer.

Induction: Up-regulated in response to beta-catenin activation.

Domain: The third and fourth KH domains encompasse the protein dimerization motif and are necessary and sufficient for RNA binding. The KH domains are important for granule formation and localization. Contains two nuclear export signals, situated within the second and fourth KH domains.

Ptm: Phosphorylated. Phosphorylation may influence mRNA translation (By similarity).

Similarity: Belongs to the RRM IMP/VICKZ family.

Similarity: Contains 4 KH domains.

Similarity: Contains 2 RRM (RNA recognition motif) domains.

Summary: This protein is a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) reacts with human, rat.

OMIM: 608288; gene. [NCBI / EBI]

PRODUCT INTERACTIONS:

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with RhoGDI, IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with Glycogen synthase kinase-3 beta, Protein (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with GSK3-beta, IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with GSK3-beta (Phospho-Ser9), IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with GSK3-beta (Phospho-Tyr216), IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with GSK3-beta (Ab-9), IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with GSK3-beta (Ab-216), IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with GSK3-beta (Phospho-Ser9) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with Rabbit anti GSK3b pS9, IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with Phospho-Ser⁹ GSK3-beta, IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with Anti-GSK3 beta pS9, IgG (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with Integrin-linked kinase(ILK1): Human, Recombinant, E Coli, Protein (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with Integrin-linked kinase (ILK1): Human, Recombinant, E Coli, Protein (GenWay Catalog #: 18-003-44208).

IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) interacts with PRKRA (protein kinase. interferon-inducible double stranded RNA dependent activator), IgG (GenWay Catalog #: 18-003-44208).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for IGF2BP1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Ioannidis.P.. (2005) J. Biol. Chem. 280 (20). 20086-20093.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: IGF2BP1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of IGF2BP1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about IGF2BP1 antibody, all related information, articles, resources about IGF2BP1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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