APOBEC3G antibody, APOBEC3G (apolipoprotein B mRNA editing enzyme. catalytic polypeptide-like 3G) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

APOBEC3G (apolipoprotein B mRNA editing enzyme. catalytic polypeptide-like 3G) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-44457

Buy APOBEC3G antibody -

Size:

Related Product Names:

- APOBEC3G antibody; APOBEC3G; ARP9, CEM15, FLJ12740, MDS019, OTTHUMP00000028911, bK150C2.7, dJ494G10.1; APOBEC3G (apolipoprotein B mRNA editing enzyme. catalytic polypeptide-like 3G)
- EC 3.5.4.-; APOBEC-related cytidine deaminase; ARCD; APOBEC-related protein; ARP-9; CEM15; CEM-15; Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; DNA dC->dU-editing enzyme APOBEC-3G

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: APOBEC3G	Gene Name Synonym: ARP9, CEM15, FLJ12740, MDS019, OTTHUMP00000028911, bK150C2.7, dJ494G10.1
Gi #: 13399304	NCBI Acc #: NP_068594.1	Swiss Prot Acc #: Q9HC16
Length (aa): 384	Mol. Weight (Da): 46408	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human APOBEC3G.

ELISA Titre: 1:1562500

Category: RNA Binding Proteins

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit IgG purified by protein A chromatography.

Clonality: Polyclonal

Crossreactivity: Human

Format: Suggested dilution at 2.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for APOBEC3G ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-APOBEC3G )

APOBEC3G antibody WB image

APOBEC3G ANTIBODY TARGET DESCRIPTION:

Synonym Names for APOBEC3G antibody: APOBEC3G; ARP9, CEM15, FLJ12740, MDS019, OTTHUMP00000028911, bK150C2.7, dJ494G10.1; EC 3.5.4.-; APOBEC-related cytidine deaminase; ARCD; APOBEC-related protein; ARP-9; CEM15; CEM-15; Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; DNA dC->dU-editing enzyme APOBEC-3G

Anti-APOBEC3G is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster. thought to result from gene duplication. on chromosome 22. Members of the cluster encode proteins that are structurally an

Function: DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. APOBEC3G binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.

Cofactor: Zinc.

Subunit: Homodimer. Interacts with APOBEC3B, APOBEC3F and HIV-1 VIF in a species specific manner.

Subcellular Location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF.

Tissue Specificity: Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression detected in permissive lymphoid and non-lymphoid cell lines.

Ptm: Ubiquitinated in the presence of HIV-1 VIF. Association with VIF targets the protein for proteolysis by the ubiquitin-dependent proteasome pathway.

Miscellaneous: Inhibits also the infectivity of retroviral particles only distantly related to HIV-1, such as the simian immunodeficiency virus (SIV), the equine infectious anemia virus (EIAV) and the murine leukemia virus (MLV).

Miscellaneous: HIV-1 does not replicate productively in nonhuman primates with the exception of the chimpanzee. The primates APOBEC3G (rhesus macaque, chimpanzee and African green monkey) are active against HIV-1 without VIF. Only the chimpanzee APOBEC3G is inhibited by HIV-1 VIF.

Miscellaneous: Accumulation of APOBEC3G induced non-lethal hypermutation could contribute to the genetic variation of primate lentiviral populations.

Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family.

Summary: This protein is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.

APOBEC3G (apolipoprotein B mRNA editing enzyme. catalytic polypeptide-like 3G) reacts with human.

OMIM: 607113; gene. [NCBI / EBI]

Products similar to APOBEC3G antibody:

IgG

APOBEC3G (apolipoprotein B mRNA editing enzyme. catalytic polypeptide-like 3G), IgG

DNA dC->dU-editing enzyme APOBEC-3G, IgG

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for APOBEC3G ANTIBODY:

Background references for antibody target are not specific to GenWay products

Rose.K.M.. et al.. (2004) J. Biol. Chem. 279 (40). 41744-41749.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: APOBEC3G antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of APOBEC3G antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about APOBEC3G antibody, all related information, articles, resources about APOBEC3G antibody are being stored on our online database. Let us know if you have questions regarding this product.

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