UGT1A1 antibody, UGT1A1 (UDP glucuronosyltransferase 1 family. polypeptide A1) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

UGT1A1 (UDP glucuronosyltransferase 1 family. polypeptide A1) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-44479

Buy UGT1A1 antibody -

Size:

Trial Size Available. Please expect delivery of trial size products to be 4 weeks.

Related Product Names:

- UGT1A1 antibody; UGT1A1; GNT1; UGT1; UGT1A1 (UDP glucuronosyltransferase 1 family. polypeptide A1)
- EC 2.4.1.17; UDP-glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT-1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: UGT1A1	Gene Name Synonym: GNT1; UGT1
Gi #: 8850236	NCBI Acc #: NP_000454.1	Swiss Prot Acc #: P22309
Length (aa): 533	Mol. Weight (Da): 59591	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human UGT1A1.

Western Blot: Suggested dilution at 2.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

ELISA Titre: 1:1562500

Category: Signal Protein

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit IgG purified by protein A chromatography.

Clonality: Polyclonal

Crossreactivity: Human

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 ul of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for UGT1A1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-UGT1A1 )

UGT1A1 antibody WB image
UGT1A1

UGT1A1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for UGT1A1 antibody: UGT1A1; GNT1; UGT1; EC 2.4.1.17; UDP-glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT-1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1

UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.

Catalytic Activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subunit: Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Subcellular Location: Microsome. Endoplasmic reticulum; Single-pass membrane protein (Potential).

Tissue Specificity: Expressed in liver. Not expressed in skin or kidney.

Disease: Defects in UGT1A1 are the cause of Gilbert syndrome [MIM:143500]. Gilbert syndrome occurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague nonspecific complaints.

Disease: Defects in UGT1A1 may be a cause of transient familial neonatal hyperbilirubinemia [MIM:237900]. The defects is characterized by excessive concentration of bilirubin in the blood, which may lead to jaundice. Breast milk jaundice is a common problem in nursing infants. It has been ascribed to various breast milk substances, but the component or combination of components that is responsible remains unclear. Defects of UGT1A1 are an underlying cause of the prolonged unconjugated hyperbilirubinemia associated with breast milk. One or more components in the milk may trigger the jaundice in infants who have such mutations. Mutations are identical to those detected in patients with Gilbert syndrome [MIM:143500], a risk factor of neonatal non-physiologic hyperbilirubinemia and a genetic factor in fasting hyperbilirubinemia.

Disease: Defects in UGT1A1 are the cause of Crigler-Najjar syndrome type I (CN-I) [MIM:218800]. CN-I patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN-I inheritance is autosomal recessive.

Disease: Defects in UGT1A1 are the cause of Crigler-Najjar syndrome type II (CN-II) [MIM:606785]. CN-II patients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN-II inheritance is autosomal dominant.

Similarity: Belongs to the UDP-glycosyltransferase family.

Summary: This protein is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This protein is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

UGT1A1 (UDP glucuronosyltransferase 1 family. polypeptide A1) reacts with human.

OMIM: 143500; phenotype. [NCBI / EBI]
191740; gene. [NCBI / EBI]
218800; phenotype. [NCBI / EBI]
237900; phenotype. [NCBI / EBI]
606785; phenotype. [NCBI / EBI]

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for UGT1A1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Wasmuth.H.E.. (2006) Hepatology 43 (4). 738-741.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: UGT1A1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of UGT1A1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about UGT1A1 antibody, all related information, articles, resources about UGT1A1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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