ATG4B antibody, ATG4B (ATG4 autophagy related 4 homolog B (S. cerevisiae)) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

ATG4B (ATG4 autophagy related 4 homolog B (S. cerevisiae)) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-003-44646

Buy ATG4B antibody -

Size:

Related Product Names:

- ATG4B antibody; ATG4B; APG4B, AUTL1, MGC1353; ATG4B (ATG4 autophagy related 4 homolog B (S. cerevisiae))
- EC 3.4.22.-; Autophagy-related protein 4 homolog B; hAPG4B; Autophagin-1; Autophagy-related cysteine endopeptidase 1; AUT-like 1 cysteine endopeptidase; APG4 autophagy 4 homolog B isoform a; Cysteine protease ATG4B

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: ATG4B	Gene Name Synonym: APG4B, AUTL1, MGC1353
Gi #: 47132611	NCBI Acc #: NP_037457.3	Swiss Prot Acc #: Q9Y4P1
Length (aa): 393	Mol. Weight (Da): 44309	Chrom Location: N/A

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human ATG4B.

ELISA Titre: 1:12500

Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity.

Source/Host: Rabbit

Purity/Purification: Rabbit IgG purified by protein A chromatography.

Clonality: Polyclonal

Crossreactivity: Human, Mouse, Rat, Dog

Format: Suggested dilution at 2.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.

Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.

Stability: Note: Avoid repeat freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for ATG4B ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols [IHC Protocol])

WB: ( anti-ATG4B )

ATG4B antibody WB image
ATG4B

ATG4B ANTIBODY TARGET DESCRIPTION:

Synonym Names for ATG4B antibody: ATG4B; APG4B, AUTL1, MGC1353; EC 3.4.22.-; Autophagy-related protein 4 homolog B; hAPG4B; Autophagin-1; Autophagy-related cysteine endopeptidase 1; AUT-like 1 cysteine endopeptidase; APG4 autophagy 4 homolog B isoform a; Cysteine protease ATG4B

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation. metamorphosis. non-apoptotic cell death. a

Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Enzyme Regulation: Inhibited by N-ethylmaleimide.

Subcellular Location: Cytoplasm (Probable).

Tissue Specificity: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.

Similarity: Belongs to the peptidase C54 family [view classification].

Summary: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This protein is a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

ATG4B (ATG4 autophagy related 4 homolog B (S. cerevisiae)) reacts with human, mouse, rat, dog.

OMIM: 611338; gene. [NCBI / EBI]

PRODUCT INTERACTIONS:

ATG4B (ATG4 autophagy related 4 homolog B (S. cerevisiae)) interacts with Gamma-aminobutyric acid receptor-associated protein-like 2, Protein (GenWay Catalog #: 18-003-44646).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for ATG4B ANTIBODY:

Background references for antibody target are not specific to GenWay products

Kumanomidou.T.. (2006) J. Mol. Biol. 355 (4). 612-618.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: ATG4B antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ATG4B antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ATG4B antibody, all related information, articles, resources about ATG4B antibody are being stored on our online database. Let us know if you have questions regarding this product.

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