Alphabetical Listing of Primary Antibodies:
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5-9
|
A
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B
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C
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D
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E
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F
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G
|
H
|
I
|
J
|
K
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L
|
M
|
N
|
O
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P
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Q
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R
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S
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T
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|
X
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|
Alphabetical Listing of Proteins:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
|
P
|
Q
|
R
|
S
|
T
|
U
|
V
|
W
|
X
|
Y
|
Z
|
Peptides
|
Secondary Antibodies
|
ELISA Kits
TNFRI Human recombinant protein
Catalog Number: 10-663-45158
Buy TNFRSF1A protein -
Size:
0.01 mg ($160.00)
0.05 mg ($350.00)
1 mg ($5,280.00)
Related Product Names:
- TNFRSF1A protein; TNFRSF1A; TNFAR; TNFR1; TNFRI Human
- Tumor necrosis factor receptor superfamily member 1A, p60, TNF-R1, TNF-RI, TNFR-I, p55, CD120a antigen, FPF, TBP1, TNF-R, TNFAR, p55-R, TNFR55, TNFR60, MGC19588.; p60; TNF-R1; TNF-RI; TNFR-I; p55; CD120a antigen; Tumor necrosis factor receptor superfamily member 1A
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
TNFRSF1A
Gene Name Synonym:
TNFAR; TNFR1
Gi #:
N/A
NCBI Acc #:
NP_001056.1
Swiss Prot Acc #:
P19438
Length (aa):
N/A
Mol. Weight (Da):
50495
Chrom Location:
N/A
Amino Acid Sequence:
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Glu-Val-Ser.
Biological Activity:
The activity was measured by its ability to neutralize apoptosis of mouse L929 cells treated with 0.25 ng/mL recombinant human TNF-a. The ED50 for this effect is typically 0.4-1 ng/mL.
Physical Appearance:
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility:
It is recommended to reconstitute the lyophilized Soluble TNF Receptor Inhibitor Human Recombinant in sterile 18MO-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Source/Host:
Ms Myeloma Cell Line (NSO)
Purity/Purification:
Greater than 95.0% as determined by (a)Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Format:
The lyophilized protein (1mg/ml) was lyophilized from sterile solution containing PBS.
Stability:
Lyophilized Soluble TNF Receptor Inhibitor although stable at room temperature for 3 weeks, should be stored desiccated below -18 C. Upon reconstitution sTNFRI Human Recombinant should be stored at 4 C between 2-7 days and for future use below -18 C.
P
Shipping:
Products may be shipped on ice pack or dry ice.
TESTING: (
secondary reagents
and
protocols
)
Not Available
TNFRSF1A PROTEIN TARGET DESCRIPTION:
Synonym Names for TNFRSF1A protein:
TNFRSF1A; TNFAR; TNFR1; Tumor necrosis factor receptor superfamily member 1A, p60, TNF-R1, TNF-RI, TNFR-I, p55, CD120a antigen, FPF, TBP1, TNF-R, TNFAR, p55-R, TNFR55, TNFR60, MGC19588.; p60; TNF-R1; TNF-RI; TNFR-I; p55; CD120a antigen; Tumor necrosis factor receptor superfamily member 1A
Soluble TNF Receptor Inhibitor Human Recombinant produced in NSO is a disulfide linked homodimer, glycosylated, polypeptide chain having a molecular mass of 48Kda but as a result of the glycosilation, the recombinant protein migrates at 55-60Kda protein in SDS-PAGE.
sTNFRI /Fc chimera (sTNF RI/Fc chimera) was fused to carboxy-terminal 6X histidine-tagged Fc part of human IgG1, via a linker peptide.
sTNFRI is purified by proprietary chromatographic techniques.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
Function:
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Subunit:
Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Secreted.
Domain:
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Domain:
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP (By similarity).
Ptm:
The soluble form is produced from the membrane form by proteolytic processing.
Disease:
Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
Similarity:
Contains 1 death domain.
Similarity:
Contains 4 TNFR-Cys repeats.
OMIM:
142680; phenotype. [
NCBI
/
EBI
]
191190; gene. [
NCBI
/
EBI
]
Products similar to TNFRSF1A protein:
IgG
Anti-Human TNF p55 Receptor (sTNFRp55), IgG
TNF receptor I (ready-to-use), IgG
CD120a. TNF-R I (p55/p60), IgG
CD120a. TNF-R I (p55/p60), IgG
CD120a. TNF-R I (p55/p60), IgG
Peptide
P55-TNFR, Peptide
sTNFR-I: Human, Recombinant, E Coli, Protein
sTNFR-I: Human, Recombinant, E Coli, Protein
sTNFR-I: Human, Recombinant, E Coli, Protein
sTNFR-I: Human, Recombinant, E Coli, Protein
PRODUCT INTERACTIONS:
TNFRI Human
interacts
with
Tumor necrosis factor, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Tumor Necrosis Factor-alpha, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF-a Human, His, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF-a Porcine, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF-a Rat, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF-a Mutant Human, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF-a Mouse, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF-a Human, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
RAT ANTI MOUSE TNF ALPHA:Biotin, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Tumor Necrosis Factor-alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR-ALPHA (TNF-alpha), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR-ALPHA (TNF-alpha), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR ALPHA (TNF-alpha), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR ALPHA (TNF-alpha), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR ALPHA (TNF-alpha), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR ALPHA (TNF-alpha), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR-alpha CROSS REACTIVE WITH RAT TNF-alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR-alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOR NECROSIS FACTOR ALPHA (E.Coli-DERIVED), Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [AS1] (Biotin), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [CH8820], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [J1D9], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [2C8], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [F6C5 ], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Tumor Necrosis Factor-alpha, ELISA_Kits
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Tumor TNF-a Factor-alpha, ELISA_Kits
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Human TNF-alpha, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF Alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF Alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF Alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Rabbit anti Rat TNF alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Goat anti TNF alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Rabbit anti TNF-alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Human TNF-alpha,, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Rat TNF-a,, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF Alpha, ELISA_Kits
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Rat Anti-Mouse TNF-, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Rat Anti-Mouse TNF-, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Rat Anti-Mouse TNF-, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Rat Anti-Mouse TNF-, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Rat Anti-Mouse TNF-, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Anti-Human TNF alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
Anti-Human TNF alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOUR NECROSIS FACTOR ALPHA (TNFa), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOUR NECROSIS FACTOR ALPHA (TNFa), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TUMOUR NECROSIS FACTOR ALPHA (TNFa), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha: Human, Recombinant, E Coli, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha: Human, Recombinant, E Coli, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha: Human, Recombinant, E Coli, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha: Human, Recombinant, E Coli, Protein
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [MP6-XT22] (PE), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [MP6-XT22] (Biotin), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [MP9-20A4] (APC), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [TA70], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [AS3], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [TN3-19.12], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [1D9], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [TA20], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [TA40], IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF alpha [MP6-XT22] (FITC), IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TNF ALPHA, IgG
(GenWay Catalog #: 10-663-45158)
.
TNFRI Human
interacts
with
TRADD, IgG
(GenWay Catalog #: 10-663-45158)
.
SUGGESTED PROTEIN REAGENTS
- GenWay offers reagents to facilitate your research with cell-based assays, Mass Spectrometry, standards, calibrators, Western blot, cell culture, antibiotics, microwell substrates, and more!
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
TNFRSF1A protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of TNFRSF1A protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TNFRSF1A protein, all related information, articles, resources about TNFRSF1A protein are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
GenWay has a diverse line of recombinant protein expression platforms, including E. coli expression, Bacliovirus expression, yeast expression, and mammalian expression. Combining the technologies of bioinformatics, protein domain analysis, gene codon optimization, protein fusion, and protein expression in different host cells, GenWay can produce soluble and functional proteins. In particular, GenWay has the capability and vector systems for expression of difficult proteins such as proteases, kinases, glycosylated and membrane proteins. We have a very high success rate (almost 100%) and can deliver the proteins in a timely fashion. This is a core competency necessary for efficient and effective production of immunogens and affinity ligands for antibody production and purification. GenWay has over 300
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Serum amyloid P-component
Signal transducer and activator of trans...
SOD Human
SPA
SREBF2 (sterol regulatory element bindin...
STAT1 Human
STAT3 Human
T-cell-specific surface glycoprotein CD2...
TaqDNA
TATA-binding protein-associated phosphop...
TCF2 (transcription factor 2. hepatic; L...
TFAM (transcription factor A. mitochondr...
Thyroid stimulating hormone receptor
Thyroid stimulating hormone receptor
Thyroid stimulating hormone receptor
TNFRI Human
TP53 (tumor protein p53 (Li-Fraumeni syn...
tPA Human
TPO Human
Trypsin Bovine
Tumor necrosis factor receptor superfami...
Ubiquitin Human
Urease
ZNF167 (zinc finger protein 167)
ZNF225 (zinc finger protein 225)
ZNF23 (zinc finger protein 23 (KOX 16))
ZNF543 (zinc finger protein 543)
ZNF627 (zinc finger protein 627)
ZNF7 (zinc finger protein 7)
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Xreactivity:
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Canine
Chicken
Drosophila
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Goat
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Human
Insect
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