PPARG protein, PPAR-g Human recombinant protein

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PPAR-g Human recombinant protein

Catalog Number: 10-663-45547

Buy PPARG protein -

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Related Product Names:

- PPARG protein; PPARG; NR1C3; PPAR-g Human
- Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG, NR1C3, PPARG1, PPARG2.; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; Peroxisome proliferator-activated receptor gamma

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: PPARG	Gene Name Synonym: NR1C3
Gi #: N/A	NCBI Acc #: NP_005028.4	Swiss Prot Acc #: P37231
Length (aa): N/A	Mol. Weight (Da): 57620	Chrom Location: N/A

Amino Acid Sequence: MTMVDTEMPFWPTNFGISSVDLSVM EDHSHSFDIKPFTTVDFSSISTPHY EDIPFTRTDPVVADYKYDLKLQEY QSAIKVEPASPPYYSEKTQLYNKPHE EPSNSLMAIECRVCGDKASGFHYG VHACEGCKGFFRRTIRLKLIYDRCD LNCRIHKKSRNKCQYCRFQK CLAVGMSHNAIRFGRMPQAEKEKLLAEIS SDIDQLNPESADLRALAKHLYDSYIKS FPLTKAKARAILTGKTTDKSPFVIY DMNSLMMGEDKIKFKHITPLQEQSKEVA IRIFQGCQFRSVEAVQEITEYAK SIPGFVNLDLNDQVTLLKYGVHEI IYTMLASLMNKDGVLISEGQGFMTREF LKSLRKPFGDFMEPKFEFAVKFNALELD DSDLAIFIAVIILSGDRPGLLNVK PIEDIQDNLLQALELQLKLNHPE SSQLFAKLLQKMTDLRQIVTEHVQLLQV IKKTETDMSLHPLLQEIYKDLYZ

Physical Appearance: Sterile Filtered clear solution.

Source/Host: E. Coli

Purity/Purification: Greater than 95% (SDS-PAGE).
Mass spectrometry of tryptic digest products for identity determination.

Format: PBS 50% glycerol, 0.01% azide.

Storage: Store at 4 C if entire vial will be used within 2-4 weeks. Store, frozen at -20 C for longer periods of time.
Avoid multiple freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

PPARG PROTEIN TARGET DESCRIPTION:

Synonym Names for PPARG protein: PPARG; NR1C3; Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG, NR1C3, PPARG1, PPARG2.; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; Peroxisome proliferator-activated receptor gamma

Peroxisome Proliferator Activated Receptor Gamma Human Recombinant is expressed in E. coli having a molecular weight of 59.2 kDa and fused to an amino terminal hexahistidine tag.

The peroxisome proliferator activated receptors (PPARs) are ligandactivated transcription factors within the nuclear receptor superfamily, which play important roles in adipogenesis, glucose homeostasis andinflammation. Three different isotypes can be distinguished; alpha, beta and gamma. PPAR?, is mainly expressed in adipose tissue and to lesser extent in colon, the immune system and the retina. Whereas PPAR? operates in the catabolism of fatty acids in the liver, PPAR? influences the storage of fatty acids in the adipose tissue and plays a role in adipocyte differentiation. PPAR? binds to DNA as a heterodimer with retinoid X receptor (RXR), activating expression of target genes after binding ligand.

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.

Subunit: Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with FAM120B (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with TGFB1I1. Interacts with DNTTIP2.

Subcellular Location: Nucleus.

Tissue Specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also are detectable in placenta, lung and ovary.

Polymorphism: Genetic variation in PPARG may influence body mass index (BMI) [MIM:606641]. BMI reflects the amount of fat, lean mass, and body build.

Polymorphism: Genetic variation in PPARG may influence abdominal body fat distribution [MIM:609830].

Disease: Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension.

Disease: Defects in PPARG may be associated with susceptibility to obesity [MIM:601665].

Disease: Defects in PPARG may be associated with colon cancer.

Disease: Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.

Disease: Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) [MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors.

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily.

Similarity: Contains 1 nuclear receptor DNA-binding domain.

OMIM: 601487; gene. [NCBI / EBI]
601665; phenotype. [NCBI / EBI]
604367; phenotype. [NCBI / EBI]
606641; phenotype. [NCBI / EBI]
609338; phenotype. [NCBI / EBI]
609830; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: PPAR signaling pathway 03320
KEGG pathway: Thyroid cancer 05216

Products similar to PPARG protein:

IgG

PGC1A, IgG

PPARGC1A, IgG

PPARG (peroxisome proliferator-activated receptor gamma), IgG

PPAR GAMMA, IgG

PPARGC1B, IgG

Protein

PPARg-477 Human, Protein

PRODUCT INTERACTIONS:

PPAR-g Human interacts with EDF1 (endothelial differentiation-related factor 1), IgG (GenWay Catalog #: 10-663-45547).

PPAR-g Human interacts with p300 [3G230], IgG (GenWay Catalog #: 10-663-45547).

PPAR-g Human interacts with p300, IgG (GenWay Catalog #: 10-663-45547).

PPAR-g Human interacts with SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), IgG (GenWay Catalog #: 10-663-45547).

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Precautions: PPARG protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of PPARG protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about PPARG protein, all related information, articles, resources about PPARG protein are being stored on our online database. Let us know if you have questions regarding this product.

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