IGF1 protein, IGF1 Human Des1-3 recombinant protein

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IGF1 Human Des1-3 recombinant protein

Catalog Number: 10-663-45847

Buy IGF1 protein -

Size:

Trial Size Available

Related Product Names:

- IGF1 protein; IGF1; IBP1; IGF1 Human Des1-3
- Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF, Des(1-3), Des1-3, Des 1-3, Des (1-3), IGF-1 (4-70).; IGF-IA; Somatomedin-C; Mechano growth factor; MGF; Insulin-like growth factor IA

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: IGF1	Gene Name Synonym: IBP1
Gi #: N/A	NCBI Acc #: NP_000609.1	Swiss Prot Acc #: P01343
Length (aa): N/A	Mol. Weight (Da): 17026	Chrom Location: N/A

Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Thr-Leu-Cys-Gly-Ala.

Biological Activity: The ED50, calculated by the dose-dependant proliferation of murine BALB\C 3T3 cells (measured by 3H-thymidine uptake) is < 1.0 ng/ml, corresponding to a specific activity of 1x106 U/mg.
For most in-vitro applications, IGF-I des1-3 exerts its biological activity in the concentration range of 0.2-20 ng/ml.

Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Solubility: It is recommended to reconstitute the lyophilized IGF-1 Des1-3 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Source/Host: E. Coli

Purity/Purification: Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Format: The protein was lyophilized after extensive dialysis against 50mM acetic acid.

Stability: Lyophilized IGF-I des(1-3) although stable at room temperature for 3 weeks, should be stored desiccated below -18 C. Upon reconstitution IGF1 des-1-3 should be stored at 4 C between 2-7 days and for future use below -18 C.
For long term storage it is r

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

IGF1 PROTEIN TARGET DESCRIPTION:

Synonym Names for IGF1 protein: IGF1; IBP1; Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF, Des(1-3), Des1-3, Des 1-3, Des (1-3), IGF-1 (4-70).; IGF-IA; Somatomedin-C; Mechano growth factor; MGF; Insulin-like growth factor IA

IGF-I Des(1-3) Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 67 amino acids and having a molecular mass of 7372 Dalton.
IGF-1 Des1-3 is purified by proprietary chromatographic techniques.

The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003).

Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

Subcellular Location: Secreted.

Disease: Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

Similarity: Belongs to the insulin family.

OMIM: 147440; gene. [NCBI / EBI]
608747; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Focal adhesion 04510
KEGG pathway: Glioma 05214
KEGG pathway: Long-term depression 04730
KEGG pathway: Melanoma 05218
KEGG pathway: Prostate cancer 05215
KEGG pathway: mTOR signaling pathway 04150
Reactome Event:Hemostasis 109582

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RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR I, Protein

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Precautions: IGF1 protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of IGF1 protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about IGF1 protein, all related information, articles, resources about IGF1 protein are being stored on our online database. Let us know if you have questions regarding this product.

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