SETD7 protein, HMTase Human recombinant protein

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HMTase Human recombinant protein

Catalog Number: 10-663-45875

Buy SETD7 protein -

Size:

Trial Size Available

Related Product Names:

- SETD7 protein; SETD7; KIAA1717; KMT7; SET7; SET9; HMTase Human
- Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7, EC 2.1.1.43, Histone H3-K4 methyltransferase, H3-K4-HMTase, SET domain-containing protein 7, Set9, SET7/9.; EC 2.1.1.43; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; SET domain-c; Histone-lysine N-methyltransferase SETD7

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: SETD7	Gene Name Synonym: KIAA1717; KMT7; SET7; SET9
Gi #: N/A	NCBI Acc #: NP_085151.1	Swiss Prot Acc #: Q8WTS6
Length (aa): N/A	Mol. Weight (Da): 40721	Chrom Location: N/A

Amino Acid Sequence: MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP

Physical Appearance: Sterile Filtered clear soultion.

Source/Host: E. Coli

Purity/Purification: Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Format: The protein (1 mg/ml) containing 50mM Tris-HCl buffer (pH7.5), 0.2M NaCl, 5mM DTT and 20% glycerol.

Stability: Store at 4 C if entire vial will be used within 1-2 weeks.
Store, frozen at -20 C for longer periods of time.
Please prevent freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

SETD7 PROTEIN TARGET DESCRIPTION:

Synonym Names for SETD7 protein: SETD7; KIAA1717; KMT7; SET7; SET9; Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7, EC 2.1.1.43, Histone H3-K4 methyltransferase, H3-K4-HMTase, SET domain-containing protein 7, Set9, SET7/9.; EC 2.1.1.43; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; SET domain-c; Histone-lysine N-methyltransferase SETD7

HMTase Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 366 amino acids & having a molecular mass of 40.7 kDa.
The HMTase purified by proprietary chromatographic techniques.

Set 7/9 is a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression.
Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.

Function: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.

Catalytic Activity: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine.

Biophysicochemical Properties:

Subunit: Interacts with IPF1/PDX-1.

Subcellular Location: Nucleus.

Tissue Specificity: Widely expressed. Expressed in pancreatic islets.

Domain: The SET domain is necessary but not sufficient for histone methyltransferase activity.

Miscellaneous: Monomethyltransferase activity is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction.

Similarity: Belongs to the histone-lysine methyltransferase family. SET7 subfamily.

Similarity: Contains 3 MORN repeats.

Similarity: Contains 1 SET domain.

OMIM: 606594; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Lysine degradation 00310

Products similar to SETD7 protein:

IgG

SET 7/9 (clone s4E5), IgG

SET7/9 Histone methyltransferase, Protein

PRODUCT INTERACTIONS:

HMTase Human interacts with Histone H3.1 (Phospho-Ser10), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with Histone H3.1 (Ab-10), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with Histone H3.1 (Phospho-Ser10) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with TAF10 (TAF10 RNA polymerase II. TATA box binding protein (TBP)-associated factor. 30kDa), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa (TAF10), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with Cellular tumor antigen p53, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 Human, Protein (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53M Human, Protein (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [SP5], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 phospho S15, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [DO-13], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [DO-7], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [Pab240], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [D01], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [3F301], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [DO-7] (ready-to-use), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [BP53-12], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with I-kappaB-alpha (Phospho-Ser32/Ser36), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Phospho-Ser15), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Phospho-Ser46), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Phospho-Ser315), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Ab-15), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Ab-46), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Ab-315), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Phospho-Ser15) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Phospho-Ser46) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (Phospho-Ser315) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with TP53 (tumor protein p53 (Li-Fraumeni syndrome)), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (a.a. 32-79), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (a.a. 88-109), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 (a.a. 306-393), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with Mouse p53, Wild Type, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with Human p53 Oncogene, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [B20.1 (BP 53.122)] antibody (ready-to-use), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 AIP1, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [BP53-12] (FITC), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [DO-2], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [DO-1], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with P53, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [B20.1 (BP 53.122)] antibody (FITC), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53, IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with P53 [SP5] (ready-to-use), IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [DO-1], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [B449], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [Pab240], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [Pab1801], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [D01], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53 [DO-2], IgG (GenWay Catalog #: 10-663-45875).

HMTase Human interacts with p53, IgG (GenWay Catalog #: 10-663-45875).

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Precautions: SETD7 protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of SETD7 protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SETD7 protein, all related information, articles, resources about SETD7 protein are being stored on our online database. Let us know if you have questions regarding this product.

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