FGFR1 protein, FGFR1 Human recombinant protein

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FGFR1 Human recombinant protein

Catalog Number: 10-663-46021

Buy FGFR1 protein -

Size:

Trial Size Available.

Related Product Names:

- FGFR1 protein; FGFR1; FGFBR; FLG; FLT2; FGFR1 Human
- FGFR-1, bFGF-R, C-FGR, CD331, fms-related tyrosine kinase 2, Pfeiffer syndrome, CEK, FLG, FLT2, KAL2, BFGFR, FGFBR, HBGFR, FGFR1/FGFR1OP2 FUSION GENE, FGFR1/ZNF198 FUSION GENE, FLG FGFR1/BCR FUSION GENE, FLG protein, FMS-LIKE GENE, N-sam tyrosine kinase,;; basic fibroblast growth factor receptor 1 isoform 10

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: FGFR1	Gene Name Synonym: FGFBR; FLG; FLT2
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: P11362
Length (aa): N/A	Mol. Weight (Da): 91868	Chrom Location: N/A

Biological Activity: Determined by its ability to inhibit human FGF acidic-dependent proliferation on R1 cells. The ED50 for this effect is typically at 15.0-30.0 ng/ml.

Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Solubility: It is recommended to reconstitute the lyophilized bFGF-R in sterile PBS not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Source/Host: Insect Cells

Purity/Purification: Greater than 90.0% as determined by:
(a)Analysis by RP-HPLC.
(b)Analysis by SDS-PAGE.

Format: CD331 was lyophilized from a concentrated (1 mg/ml) sterile solution containing no additives.

Stability: Lyophilized FGFR1A although stable at room temperature for 3 weeks, should be stored desiccated below -18 C. Upon reconstitution FGFR1 should be stored at 4 C between 2-7 days and for future use below -18 C.
For long term storage it is recommended to a

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

FGFR1 PROTEIN TARGET DESCRIPTION:

Synonym Names for FGFR1 protein: FGFR1; FGFBR; FLG; FLT2; FGFR-1, bFGF-R, C-FGR, CD331, fms-related tyrosine kinase 2, Pfeiffer syndrome, CEK, FLG, FLT2, KAL2, BFGFR, FGFBR, HBGFR, FGFR1/FGFR1OP2 FUSION GENE, FGFR1/ZNF198 FUSION GENE, FLG FGFR1/BCR FUSION GENE, FLG protein, FMS-LIKE GENE, N-sam tyrosine kinase,;; basic fibroblast growth factor receptor 1 isoform 10

Soluble FGFR-1a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric, glycosylated, Polypeptide chain and having a molecular mass of 190 kDa.
The FGFR1 is purified by proprietary chromatographic techniques.

Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the ß isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.

Function: Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF).

Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit: Interacts with SHB. Interacts with KLB (By similarity).

Subcellular Location: Membrane; Single-pass type I membrane protein.

Ptm: Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.

Disease: Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.

Disease: Defects in FGFR1 are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadism is a condition characterized by abnormally decreased gonadal function, with retardation of growth and sexual development. Hypogonadotropic hypogonadism is due to inadequate secretion of gonadotropins. It results from failure to release sufficient gonadotropin-releasing hormone.

Disease: Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous.

Disease: Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant.

Disease: Defects in FGFR1 are the cause of non-syndromic trigonocephaly [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome.

Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.

Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.

Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Similarity: Contains 1 protein kinase domain.

OMIM: 101600; phenotype. [NCBI / EBI]
136350; gene. [NCBI / EBI]
146110; phenotype. [NCBI / EBI]
147950; phenotype. [NCBI / EBI]
166250; phenotype. [NCBI / EBI]
190440; phenotype. [NCBI / EBI]

Products similar to FGFR1 protein:

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FGFR1, IgG

FGFR1 alpha [M1C4], IgG

FGFR1 [M19B2], IgG

FGF Receptor 1, IgG

FGF Receptor 1 alpha, IgG

PRODUCT INTERACTIONS:

FGFR1 Human interacts with E-cadherin, Reagents (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with E Cadherin [67A4], IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with pan Cadherin [CH-19], IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Human E-cadherin EIA Kit, ELISA_Kits (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with E-Cadherin, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Cadherin-E Human, Protein (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with E Cadherin [DECMA-1], IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with pan Cadherin [CH-19] (FITC), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with pan Cadherin (ready-to-use), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with pan Cadherin, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with E Cadherin (ready-to-use), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with E Cadherin, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with CD324, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with E-Cadherin, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with E-Cadherin Phospho (pS838/840), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with CTNNB1, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with CATENIN, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with b-Catenin (CTNNB1) Dephospho, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with b-Catenin (CTNNB1), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with BETA-CATENIN, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta Catenin [6F9], IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta Catenin [15B8], IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta-Catenin (Phospho-Thr41/Ser45), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with b-Catenin (Ab-41/45), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta-Catenin (Phospho-Ser33), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta-Catenin (Phospho-Ser37), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin (Ab-33), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin (Ab-37), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta-Catenin (Phospho-Thr41/Ser45) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta-Catenin (Phospho-Ser33) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta-Catenin (Phospho-Ser37) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin beta, C-terminal (exon 14), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin beta, N-terminal (exon 2), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin, beta, Core, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin beta, C-terminal (a.a. 769-781), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin, beta, dephosphorylated (35-50), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin beta, pTyr 86, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin beta, pTyr 654, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Catenin beta,(exon 3), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta Catenin phospho S33, S37 [BC-22], IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta Catenin [15B8] (Cy3), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta Catenin (ready-to-use), IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta Catenin, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta Catenin phospho S33 [BC-76], IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with beta-catenin, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Beta-Catenin, IgG (GenWay Catalog #: 10-663-46021).

FGFR1 Human interacts with Beta-Catenin Phospho (pT41/pT45), IgG (GenWay Catalog #: 10-663-46021).

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Precautions: FGFR1 protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of FGFR1 protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FGFR1 protein, all related information, articles, resources about FGFR1 protein are being stored on our online database. Let us know if you have questions regarding this product.

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