BAD protein, BAD Protein Human recombinant protein

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BAD Protein Human recombinant protein

Catalog Number: 10-663-46120

Buy BAD protein -

Size:

Related Product Names:

- BAD protein; BAD; BBC6; BCL2L8; BAD Protein Human
- Bcl2 antagonist of cell death, BAD, Bcl-2-binding component 6, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like 8 protein, BAD Protein, BBC6, BCL2L8.; BAD; Bcl-2-binding component 6; Bcl-XL/Bcl-2-associated death promoter; Bcl-2-like 8 protein; Bcl2 antagonist of cell death

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: BAD	Gene Name Synonym: BBC6; BCL2L8
Gi #: N/A	NCBI Acc #: NP_004313.1	Swiss Prot Acc #: Q92934
Length (aa): N/A	Mol. Weight (Da): 18392	Chrom Location: N/A

Physical Appearance: Sterile Filtered clear solution.

Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 51kDa.

Useful Applications: ELISA, Inhibition Assays, Western Blotting

Source/Host: E. Coli

Format: BAD protein at 100ug/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol.

Stability: Store vial at -20 C to -80 C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

BAD PROTEIN TARGET DESCRIPTION:

Synonym Names for BAD protein: BAD; BBC6; BCL2L8; Bcl2 antagonist of cell death, BAD, Bcl-2-binding component 6, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like 8 protein, BAD Protein, BBC6, BCL2L8.; BAD; Bcl-2-binding component 6; Bcl-XL/Bcl-2-associated death promoter; Bcl-2-like 8 protein; Bcl2 antagonist of cell death

Bcl2 antagonist of cell death (BAD) Human Recombinant full length protein expressed in E.coli.

The Bcl-2 family of protein is characterized by its ability to modulate cell death under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. Bad exhibits homology to Bcl-2 limited to the BH1, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2.

Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Subunit: Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity).

Subcellular Location: Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.

Tissue Specificity: Expressed in a wide variety of tissues.

Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

Ptm: Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation (By similarity).

Similarity: Belongs to the Bcl-2 family.

OMIM: 603167; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Amyotrophic lateral sclerosis (ALS) 05030
KEGG pathway: Apoptosis 04210
KEGG pathway: Chronic myeloid leukemia 05220
KEGG pathway: Colorectal cancer 05210
KEGG pathway: Endometrial cancer 05213
KEGG pathway: ErbB signaling pathway 04012
KEGG pathway: Focal adhesion 04510
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: Melanoma 05218
KEGG pathway: Neurodegenerative Disorders 01510
KEGG pathway: Non-small cell lung cancer 05223
KEGG pathway: Pancreatic cancer 05212
KEGG pathway: Prostate cancer 05215
KEGG pathway: VEGF signaling pathway 04370
Reactome Event:Apoptosis 109581
Reactome Event:Signalling by NGF 166520

Products similar to BAD protein:

IgG

BAD (Ab-136), IgG

BAD (Phospho-Ser112), IgG

Bad phospho S128, IgG

Bad phospho S112 antibody, IgG

BAD (Ab-112), IgG

Peptide

BAD (Phospho-Ser155) Antibody Blocking Peptide, Peptide

BAD (Phospho-Ser112) Antibody Blocking Peptide, Peptide

PRODUCT INTERACTIONS:

BAD Protein Human interacts with Apoptosis regulator Bcl-2, IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Bcl-2, IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Bcl2 [SPM117] (ready-to-use), IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Bcl2 [100/D5], IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Bcl2 [124], IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Bcl2 [124] (ready-to-use), IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with BCL-2 (Phospho-Thr56), IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with BCL-2 (Phospho-Ser70), IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with BCL-2 (Ab-56), IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with BCL-2 (Ab-70), IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with BCL-2 (Phospho-Thr56) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with BCL-2 (Phospho-Ser70) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with BCL2 (B-cell CLL/lymphoma 2), IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Bcl-2 Human, Protein (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Anti-Bcl-2, IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Bcl2, IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Bcl-2, IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with BCL 2L2 [90316.11], IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Growth factor receptor-bound protein 2, Protein (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Grb2, IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with GRB2 [R11], IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with GRB2 [R13], IgG (GenWay Catalog #: 10-663-46120).

BAD Protein Human interacts with Grb2, IgG (GenWay Catalog #: 10-663-46120).

SUGGESTED PROTEIN REAGENTS - GenWay offers reagents to facilitate your research with cell-based assays, Mass Spectrometry, standards, calibrators, Western blot, cell culture, antibiotics, microwell substrates, and more!

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: BAD protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of BAD protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about BAD protein, all related information, articles, resources about BAD protein are being stored on our online database. Let us know if you have questions regarding this product.

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