YEATS4 protein, YEATS domain-containing protein 4 recombinant protein

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YEATS domain-containing protein 4 recombinant protein

Catalog Number: 10-288-21941F

Buy YEATS4 protein -

Size:

Related Product Names:

- YEATS4 protein; YEATS4; GAS41; YAF9; NUBI-1; 4930573H17Rik; YEATS domain-containing protein 4
- Glioma-amplified sequence-41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1; Glioma-amplified sequence-41

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: YEATS4	Gene Name Synonym: GAS41; YAF9; NUBI-1; 4930573H17Rik
Gi #: 5729838	NCBI Acc #: NP_006521.1	Swiss Prot Acc #: O95619
Length (aa): 227	Mol. Weight (Da): 26499	Chrom Location: 12q13-q15

Linear Protein Map of Expressed Protein (sequence source from above GI#)

Source/Host: E Coli

Purity/Purification: 95%

Crossreactivity: human

Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3.

Storage: -70 degree C. Avoid frequent freeze and thaw.

Stability: 6-12 months at -70 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for YEATS4 PROTEIN:

MS, SDS: Tested

ELISA, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

SDS: Analysis of GAS41 Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining ( anti-YEATS4 protein )

YEATS4 protein SDS image
YEATS4

YEATS4 PROTEIN TARGET DESCRIPTION:

Synonym Names for YEATS4 protein: YEATS4; GAS41; YAF9; NUBI-1; 4930573H17Rik; Glioma-amplified sequence-41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1; Glioma-amplified sequence-41

Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Subunit: Component of numerous complexes with chromatin remodelling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit HTATIP/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, TCFL1/YL1 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.

Subcellular Location: Nucleus.

Tissue Specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Similarity: Contains 1 YEATS domain.

Summary: The protein encoded by this gene is found in the nucleoli It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This protein has been shown to be amplified in tumors.

YEATS domain-containing protein 4 reacts with human.

OMIM: 602116; gene. [NCBI / EBI]

Products similar to YEATS4 protein:

IgG

YEATS4 (YEATS domain containing 4), IgG

YEATS domain containing 4 (YEATS4), IgG

SUGGESTED PROTEIN REAGENTS - GenWay offers reagents to facilitate your research with cell-based assays, Mass Spectrometry, standards, calibrators, Western blot, cell culture, antibiotics, microwell substrates, and more!

BACKGROUND REFERENCES for YEATS4 PROTEIN:

Background references for antibody target are not specific to GenWay products

[1] Park,J.H. and Roeder,R.G., et al.
     GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation
[2] Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I., Parmely,T.J., Conaway,R.C. and Conaway,J.W.
     Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex
[3] Lauffart,B., Gangisetty,O. and Still,I.H., et al.
     Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2
[4] Zimmermann,K., Ahrens,K., Matthes,S., Buerstedde,J.M., Stratling,W.H. and Phi-van,L.
     Targeted disruption of the GAS41 gene encoding a putative transcription factor indicates that GAS41 is essential for cell viability
[5] Lauffart,B., Howell,S.J., Tasch,J.E., Cowell,J.K. and Still,I.H., et al.
     Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells
[6] , Fischer U., Heckel D., Michel A., Janka M., Hulsebos T., Meese E.
     Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I.
[7] , Harborth J., Weber K., Osborn M.
     GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA.
[8] , Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., et al.
     Complete sequencing and characterization of 21,243 full-length human cDNAs.
[9] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
     Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
[10] , Cai Y., Jin J., Tomomori-Sato C., Sato S., Sorokina I., Parmely T.J., Conaway R.C., Conaway J.W.
     Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

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Precautions: YEATS4 protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of YEATS4 protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about YEATS4 protein, all related information, articles, resources about YEATS4 protein are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

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