XBP1 protein, X box-binding protein 1 recombinant protein

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X box-binding protein 1 recombinant protein

Catalog Number: 10-288-21960F

Buy XBP1 protein -

Size:

Related Product Names:

- XBP1 protein; XBP1; TREB5; XBP2; X box-binding protein 1
- XBP-1; Tax-responsive element-binding protein 5; X-box binding protein 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: XBP1	Gene Name Synonym: TREB5; XBP2
Gi #: 14110395	NCBI Acc #: NP_005071.2	Swiss Prot Acc #: P17861
Length (aa): 261	Mol. Weight (Da): 28695	Chrom Location: N/A

Linear Protein Map of Expressed Protein (sequence source from above GI#)

Fusion: T7 tag at N-terminus.

Source/Host: E Coli

Purity/Purification: 95%

Crossreactivity: human

Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3.

Storage: -70 degree C. Avoid frequent freeze and thaw.

Stability: 6-12 months at -70 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for XBP1 PROTEIN:

MS, SDS: Tested

ELISA, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

SDS: Analysis of XBP1 Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining. ( anti-XBP1 protein )

XBP1 protein SDS image
XBP1

XBP1 PROTEIN TARGET DESCRIPTION:

Synonym Names for XBP1 protein: XBP1; TREB5; XBP2; XBP-1; Tax-responsive element-binding protein 5; X-box binding protein 1

Function: Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the tax-responsive element (TRE) of HTLV-I.

Subcellular Location: Nucleus.

Induction: Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress.

Similarity: Belongs to the bZIP family.

Similarity: Contains 1 bZIP domain.

Summary: This protein is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This protein product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter. Adding to the list of functional possibilities is a recent report from studies of knockout mice showing that this gene is essential for hepatocyte growth. A pseudogene has been identified and localized to chromosome 5.

X box-binding protein 1 reacts with human.

OMIM: 194355; gene. [NCBI / EBI]

Products similar to XBP1 protein:

IgG

MUNC18 / STXBP1 (isoform a), IgG

Tax1 (human T-cell leukemia virus type I) binding protein 1 (TAX1BP1), IgG

Rabbit anti XBP-1, N-terminal, IgG

MUNC-18, IgG

XBP1 / TREB5, IgG

SUGGESTED PROTEIN REAGENTS - GenWay offers reagents to facilitate your research with cell-based assays, Mass Spectrometry, standards, calibrators, Western blot, cell culture, antibiotics, microwell substrates, and more!

BACKGROUND REFERENCES for XBP1 PROTEIN:

Background references for antibody target are not specific to GenWay products

[1] Yoshida,H., Oku,M., Suzuki,M. and Mori,K., et al.
     pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
[2] Jonsson,E.G., Cichon,S., Schumacher,J., Abou Jamra,R., Schulze,T.G., Deschner,M., Forslund,K., Hall,H., Propping,P.,, et al.
     Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia
[3] Kusumi,I., Masui,T., Kakiuchi,C., Suzuki,K., Akimoto,T., Hashimoto,R., Kunugi,H., Kato,T. and Koyama,T.
     Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
[4] Lotz,C., Mutallib,S.A., Oehlrich,N., Liewer,U., Ferreira,E.A., Moos,M., Hundemer,M., Schneider,S., Strand,S., Huber,C.,, et al.
     Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL
[5] Kanemoto,S., Kondo,S., Ogata,M., Murakami,T., Urano,F. and Imaizumi,K.
     XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress
[6] , Liou H.-C., Boothby M.R., Finn P.W., Davidon R., Nabavi N., Zeleznik-Le N.J., Ting J.P.-Y., Glimcher L.H.
     A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.
[7] , Yoshimura T., Fujisawa J., Yoshida M.
     Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.
[8] , Ponath P.D., Fass D., Liou H.C., Glimcher L.H., Strominger J.L.
     The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes.
[9] , Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K.
     XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
[10] , Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., et al.
     A genome annotation-driven approach to cloning the human ORFeome.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: XBP1 protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of XBP1 protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about XBP1 protein, all related information, articles, resources about XBP1 protein are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

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