CYR61 protein, Protein CYR61 recombinant protein

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Protein CYR61 recombinant protein

Catalog Number: 10-288-21976F

Buy CYR61 protein -

Size:

Related Product Names:

- CYR61 protein; CYR61; CCN1; GIG1; IGFBP10; Protein CYR61
- Cysteine-rich, angiogenic inducer, 61; Insulin-like growth factor-binding protein 10; Protein GIG1; Cysteine-rich, angiogenic inducer, 61; cysteine-rich heparin-binding protein 61; cysteine-rich, anigogenic inducer, 61

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CYR61	Gene Name Synonym: CCN1; GIG1; IGFBP10
Gi #: 4504613	NCBI Acc #: NP_001545.1	Swiss Prot Acc #: O00622
Length (aa): 381	Mol. Weight (Da): 42027	Chrom Location: 1p31-p22

Linear Protein Map of Expressed Protein (sequence source from above GI#)

Fusion: His tag at N-terminus.

Source/Host: E Coli

Purity/Purification: 90%

Crossreactivity: human

Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3, 10mM DTT.

Storage: -70 degree C. Avoid frequent freeze and thaw.

Stability: 6-12 months at -70 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CYR61 PROTEIN:

MS, SDS: Tested

ELISA, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

SDS: Analysis of CYR61Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining. ( anti-CYR61 protein )

CYR61 protein SDS image
CYR61

CYR61 PROTEIN TARGET DESCRIPTION:

Synonym Names for CYR61 protein: CYR61; CCN1; GIG1; IGFBP10; Cysteine-rich, angiogenic inducer, 61; Insulin-like growth factor-binding protein 10; Protein GIG1; Cysteine-rich, angiogenic inducer, 61; cysteine-rich heparin-binding protein 61; cysteine-rich, anigogenic inducer, 61

Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. Cyr61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Subunit: Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

Subcellular Location: Secreted protein.

Similarity: Belongs to the CCN family.

Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain.

Similarity: Contains 1 IGFBP domain.

Similarity: Contains 1 TSP type-1 domain.

Similarity: Contains 1 VWFC domain.

Protein CYR61 reacts with human.

OMIM: 602369; gene. [NCBI / EBI]

Products similar to CYR61 protein:

IgG

Lactoferrin, IgG

PER3 (period homolog 3 (Drosophila)), IgG

Calcineurin A, IgG

Cyclin A [AT10.2], IgG

Cyclin A [E72.1], IgG

SUGGESTED PROTEIN REAGENTS - GenWay offers reagents to facilitate your research with cell-based assays, Mass Spectrometry, standards, calibrators, Western blot, cell culture, antibiotics, microwell substrates, and more!

BACKGROUND REFERENCES for CYR61 PROTEIN:

Background references for antibody target are not specific to GenWay products

[1] Leu,S.J., Lam,S.C. and Lau,L.F., et al.
     Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells
[2] Tsai,M.S., Bogart,D.F., Castaneda,J.M., Li,P. and Lupu,R., et al.
     Cyr61 promotes breast tumorigenesis and cancer progression
[3] Schober,J.M., Chen,N., Grzeszkiewicz,T.M., Jovanovic,I., Emeson,E.E., Ugarova,T.P., Ye,R.D., Lau,L.F. and Lam,S.C.
     Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions
[4] Tsai,M.S., Bogart,D.F., Li,P., Mehmi,I. and Lupu,R., et al.
     Expression and regulation of Cyr61 in human breast cancer cell lines
[5] Leng,E., Malcolm,T., Tai,G., Estable,M. and Sadowski,I., et al.
     Organization and expression of the Cyr61 gene in normal human fibroblasts
[6] , Albrecht C., von der Kammer H., Klaudiny J., Mayhaus M., Nitsch R.M.
     Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
[7] , Jay P., Berge-Lefranc J.-L., Marsollier C., Mejean C., Taviaux S., Berta P.
     The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.
[8] , Martinerie C., Viegas-Pequignot E., Nguyen V.C., Perbal B.
     Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.
[9] , Kolesnikova T.V., Lau L.F.
     Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
[10] , Bi A.B., Yu L.
     Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: CYR61 protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CYR61 protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CYR61 protein, all related information, articles, resources about CYR61 protein are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

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